Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma via mediation of miR-874/eEF-2K/TG2 axis

Article Dermatology

MicroRNA31 and MMP-1 contribute to the differentiated pathway of invasion -with enhanced epithelial-to-mesenchymal transition- in squamous cell carcinoma of the skin

M. T. Fernandez-Figueras et al.

Summary: The study found higher expression of miRNA31 and MMP-1 in the differentiated pathway, and more marked PTEN loss in the classical pathway. These findings support the significant roles of miRNA31 and MMP-1 in cSCC development.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2022)

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Article Gastroenterology & Hepatology

LncRNA SNHG3 Facilitates the Malignant Phenotype of Cholangiocarcinoma Cells via the miR-3173-5p/ERG Axis

Zeng-Peng Sun et al.

Summary: The oncogenic lncRNA SNHG3 is upregulated in cholangiocarcinoma cells and its knockdown inhibits proliferation and migration by sponging miR-3173-5p to release suppression of ERG. This suggests a potential therapeutic target for CCA by targeting the SNHG3/miR-3173-5p/ERG axis.

JOURNAL OF GASTROINTESTINAL SURGERY (2022)

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Article Medicine, Research & Experimental

Tanshinone IIA protects against chronic obstructive pulmonary disease via exosome-shuttled miR-486-5p

Dongdong Tian et al.

Summary: Danshen, a Chinese herbal medicine, may protect against the development of chronic obstructive pulmonary disease (COPD) through exosome-shuttled signals. miR-486-5p plays a key role in mediating the protective effects by targeting phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1).

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

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Article Integrative & Complementary Medicine

The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

Shimaa S. Khaled et al.

Summary: This study evaluated the preventive effects of naringin and naringenin on paclitaxel-induced kidney and heart damage. The results showed that treatment with naringin and naringenin improved kidney and heart dysfunction caused by paclitaxel and reduced histopathological damage. Additionally, naringin and naringenin exhibited antioxidant activities and reversed oxidative stress and restored antioxidant defense. The combination of naringin and naringenin was the most effective.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice

Ke-Yu Peng et al.

Summary: The study demonstrated that JF and DT alone or in combination effectively ameliorated DSS-induced ulcerative colitis in mice, possibly by inhibiting the TLR4/PI3K/AKT/mTOR signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Cell Biology

Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis

Yangyang Liu et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer

Liang Zeng et al.

Summary: The study shows that tanshinone IIA derivative 4 can induce DNA damage by stabilizing multiple G4 DNAs, inhibiting the growth, metastasis, and angiogenesis of triple-negative breast cancer cells.

BIOORGANIC CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway

Fangyuan Cao et al.

Summary: A novel dual inhibitor targeting HDAC and MIF was found to be toxic to EGFR mutated NSCLC cells, enhancing TKI efficacy and overcoming therapy resistance.

BIOORGANIC CHEMISTRY (2021)

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Article Oncology

EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma

Mingming Deng et al.

Summary: In this study, we found that increased EFNA3 expression in LUAD patients predicted worse clinical prognosis, promoted LUAD cell proliferation and glycolysis ability, and was related to immunotherapy response. Mechanistically, EFNA3 may be involved in pathways related to nuclear division, synaptic function, and ion channel activity. Furthermore, EFNA3 was negatively correlated with immunity, stromal infiltration, and various tumor infiltrating immune cells (TIICs), but positively associated with multiple immunotherapy biomarkers.

CANCER CELL INTERNATIONAL (2021)

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Article Chemistry, Medicinal

Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis

He Huang et al.

Summary: The structural optimization of tanshinone IIA led to the discovery of a new analogue, 2f, with potent anti-cancer properties, including inhibition of tubulin assembly, induction of apoptotic cell death, and suppression of cell proliferation, migration, and invasion. Additionally, 2f exhibited promising in vivo anti-angiogenic effects.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Medicine, Research & Experimental

circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1

Yuanshan Yao et al.

Summary: Our research revealed that circ_0018414 functions as a tumor inhibitor in LUAD by inhibiting cell proliferation and stemness while promoting apoptosis. Furthermore, circ_0018414 upregulation led to inactivation of the Wnt/beta-catenin pathway by enhancing the expression of DKK1 through sponging miR-6807-3p. This study suggests a potential therapeutic target for LUAD treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype

Xi Chen et al.

Summary: Transglutaminase 2 (TG2) plays a key role in the survival of epidermal squamous cell carcinoma cells by maintaining hepatocyte growth factor (HGF) signaling. Inhibiting TG2 reduces MET receptor activity, downstream MEK1/2 and ERK1/2 activity, and subsequently decreases cancer cell invasion and migration, and stem and EMT marker expression. TG2-dependent MET signaling may be a potential target for anti-cancer therapy.

MOLECULAR CANCER RESEARCH (2021)

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Article

Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer

Wei Zou et al.

Oxidative Medicine and Cellular Longevity (2021)

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Article Cell Biology

circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3

Jiapeng Bao et al.

Summary: This study revealed the crucial role of circFAM160A2-miR-505-3p-SIRT3 axis in osteoarthritis progression, showing that circFAM160A2 can promote mitochondrial stabilization and reduce apoptosis in OA chondrocytes by targeting miR-505-3p and SIRT3, which may be a potential therapeutic target for OA therapy.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer

Yu Ding et al.

Summary: With the advancement in diagnostic technology, the importance of exploring molecular targets for improving the treatment and prognosis of papillary thyroid carcinoma (PTC) is evident. Studies have shown the involvement of FAM84A in the development of various tumors, making it a potential diagnostic and therapeutic target for PTC.

MOLECULAR ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway

Ziheng Li et al.

Summary: This study identified the molecular mechanism of Tanshinone IIA (TSA) in the treatment of Lung Adenocarcinoma (LUAD) through a combination of network bio-information analysis and biological experiments in vitro. The results showed that TSA suppresses LUAD progression by inducing cell apoptosis, arresting cell cycle and regulating specific pathways and genes, such as CCNA2-CDK2 complex and AURKA/PLK1 pathway.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma

Zhencong Chen et al.

Summary: This study explores the cellular diversity and molecular complexity of the TME and ITH in different stages of LUAD using single-cell transcriptome analysis. Results reveal that advanced LUAD cells have a more complex TME and higher ITH level compared to early malignant cells, with significant diversity in cell-cell communication between different lesions of LUAD at the single-cell level.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Nonnegative matrix factorization-based bioinformatics analysis reveals that TPX2 and SELENBP1 are two predictors of the inner sub-consensuses of lung adenocarcinoma

Haiwei Wang et al.

Summary: This study utilized nonnegative matrix factorization (NMF) clustering to classify LUAD patients and cell lines, revealing associations between different sub-consensuses with survival rates, gene expressions, and treatment sensitivity. The results further demonstrated that NMF is a robust and effective classification method for LUAD.

CANCER MEDICINE (2021)

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Article Medicine, General & Internal

Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells

Yueqing Wang et al.

Summary: The study revealed that Circ_0007142 regulates the growth, apoptosis, and ferroptosis of CRC cells by modulating miR-874-3p and GDPD5. This suggests that Circ_0007142 may serve as a valuable marker for ferroptosis in CRC therapy.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Tanshinone IIA regulates microRNA-125b/foxp3/caspase-1 signaling and inhibits cell viability of nasopharyngeal carcinoma

Youhu Wang et al.

Summary: The study identified tanshinone IIA as an effective drug that could suppress the proliferation of HK1 cells by enhancing pyroptosis through regulation of the miR-125b/foxp3/caspase-1 signaling pathway. The results showed that tanshinone IIA enhanced pyroptosis in a dose-dependent manner, providing evidence for its potential in treating NPC.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

Nuclear Transglutaminase 2 interacts with topoisomerase II? to promote DNA damage repair in lung cancer cells

Xiao Lei et al.

Summary: The study identified TG2 as a new component of the DSB repair complex, which interacts directly with TOPOII alpha to promote repair. TG2 deficient cells lose the capacity for repair and become sensitive to ionizing radiation. Specific inhibition of the TG2-TOPOII alpha interaction can significantly inhibit repair and increase sensitivity in lung cancer cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Pathology

CHML targeted by miR-199a-3p promotes non-small cell lung cancer cell growth via binding to Rab5A

Changqing Dong et al.

Summary: The study reveals that CHML is an oncogene in NSCLC, promoting the proliferation and inhibiting apoptosis of NSCLC cells through binding to Rab5A. miR-199a3p targets CHML in this cancer.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Toxicology

Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway

Ruijuan Guan et al.

Summary: Sodium tanshinone IIA sulfonate (STS) attenuates cigarette smoke (CS)-induced alveolar epithelial cell (AEC) apoptosis by enhancing mitochondrial function and reducing oxidative stress through the SIRT1 pathway.

TOXICOLOGICAL SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Naiyan Lu et al.

Summary: The study showed that black phosphorus nanoparticles can significantly enhance osteogenic differentiation of ectodermal mesenchymal stem cells in vitro, without affecting cell proliferation. The mechanism involves promoting osteogenic differentiation by upregulating the expression of transglutaminase 2.

NANOSCALE RESEARCH LETTERS (2021)

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Article Plant Sciences

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Lijie Liu et al.

Summary: Tanshinone IIA has been found to significantly reduce tumor formation, decrease intestinal permeability, and reduce neutrophil infiltration in mice with colitis-associated colorectal tumorigenesis. The mechanism involves downregulation of the NF-kappa B signaling pathway and inhibition of intestinal inflammation, suggesting its therapeutic potential for colorectal cancer.

PHARMACEUTICAL BIOLOGY (2021)

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Review Neurosciences