4.6 Article

Danggui Buxue decoction alleviates cyclophosphamide-induced myelosuppression by regulating β-hydroxybutyric acid metabolism and suppressing oxidative stress

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation

Yanglin Wu et al.

Summary: The study confirmed that beta-hydroxybutyrate (BHB) can inhibit CoCrMo alloy particles induced osteolysis, and achieve its anti-inflammatory effect by deactivating NLRP3 inflammasome. Furthermore, beta-hydroxybutyrate (BHB) also affects the differentiation and function of osteoclast, contributing to the alleviation of osteolysis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Environmental Sciences

Predicting COVID-19 future trends for different European countries using Pearson correlation

Jihan Muhaidat et al.

Summary: Accurate forecasting of COVID-19 cases and trends is crucial for governments and organizations. While reliable data is now available, specific correlations between different countries in terms of case trends have not been identified. The study found strong correlations among European countries, including countries geographically distant from each other.

EURO-MEDITERRANEAN JOURNAL FOR ENVIRONMENTAL INTEGRATION (2022)

Article Pharmacology & Pharmacy

Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide

He Zhang et al.

Summary: This study compared the effects of PDS and PTS on preventing myelosuppression in mice induced by CP. The results showed that both PDS and PTS improved most indicators, with PDS having a better preventive effect.

FRONTIERS IN PHARMACOLOGY (2022)

Article Cell Biology

The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats

Mahrokh Samadi et al.

Summary: The study showed that tropisetron treatment reversed renal damage in diabetic rats by possibly suppressing oxidative stress and altering SIRT1, FOXO3a, and claudin-1 levels.

CELL STRESS & CHAPERONES (2021)

Article Integrative & Complementary Medicine

Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF

Huaiquan Liu et al.

Summary: The study explored the molecular mechanism of Danggui Buxue Decoction (DBD) in intervening premature ovarian failure (POF). The results showed that DBD could treat POF by regulating the balance of ESR and AR in the TP53-AKT signaling pathway, with the core compounds quercetin and kaempferol, and critical targets TP53, IL6, ESR1, AKT1, and AR playing important roles.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Review Plant Sciences

Ameliorative effects of ginsenosides on myelosuppression induced by chemotherapy or radiotherapy

Mengjiao He et al.

Summary: The study reviewed previous research on the effects of ginsenosides in alleviating myelosuppression and their mechanisms of action. Ginsenosides play a crucial role in relieving myelosuppression mainly by restoring hematopoiesis and immunity. Therefore, ginsenosides may be potential candidates for the treatment of myelosuppression induced by chemotherapy or radiotherapy.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Medicine, General & Internal

Traditional Chinese medicine on treating myelosuppression after chemotherapy A protocol for systematic review and meta-analysis

Sihang Yang et al.

Summary: The study aims to evaluate the efficacy and safety of traditional Chinese medicine treatment for myelosuppression after chemotherapy. The meta-analysis could provide evidence for clinicians and help patients make informed decisions.

MEDICINE (2021)

Article Pharmacology & Pharmacy

Anticonstriction Effect of MCA in Rats by Danggui Buxue Decoction

Ying Guo et al.

Summary: Danggui Buxue decoction, containing Angelicae Sinensis Radix and Astragali Radix, can relax the rat MCA with higher efficacy on precontracted vessels. Angelicae Sinensis Radix shows superior vasodilator effects on KCl-contracted MCA compared to other components. DBD exhibits stronger vasodilator effects on MCA at various concentrations.

FRONTIERS IN PHARMACOLOGY (2021)

Review Oncology

Hematopoietic stem cell stretches and moves in its bone marrow niche

Walison N. Silva et al.

Summary: Recent studies using advanced technologies have successfully visualized endogenous hematopoietic stem cells in live animals, revealing that quiescent stem cells are more mobile than previously thought. This new understanding is crucial for research on hematopoietic stem cells and the treatment of various hematological diseases.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Article Plant Sciences

Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression

Yan Liu et al.

Summary: The combination of DBD and Gem showed enhanced anticancer effect and improved hematopoietic function in A549 nude mice model. DBD regulated HuR, dCK and Nrf2, and increased the expression of thrombopoietin and granulocyte-macrophage colony stimulating factor.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Oncology

Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020

Haibo Qiu et al.

Summary: Cancer is a major cause of death and economic burden in China, with lower incidence but higher mortality and DALY rates compared to the US and UK. The cancer spectrum in China is changing, with increasing burden of certain cancers and a shift towards patterns seen in developed countries.

CANCER COMMUNICATIONS (2021)

Review Oncology

Systemic immunity in cancer

Kamir J. Hiam-Galvez et al.

Summary: Understanding systemic immune landscape beyond the tumour microenvironment is crucial in assessing the effectiveness of immunotherapy in cancer treatment. Despite the potential of immunotherapy to induce new immune responses, compromised immune responses in individuals with tumors may limit its efficacy.

NATURE REVIEWS CANCER (2021)

Article Biochemistry & Molecular Biology

Blockade of myeloid-derived suppressor cell function by valproic acid enhanced anti-PD-L1 tumor immunotherapy

Adeleye O. Adeshakin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Endocrinology & Metabolism

Ketone Body, 3-Hydroxybutyrate: Minor Metabolite Major Medical Manifestations

Niels Moller

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Review Biochemistry & Molecular Biology

Regulating the Regulators: The Role of Histone Deacetylase 1 (HDAC1) in Erythropoiesis

Min Young Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Physiology

METABOLOMICS FOR INVESTIGATING PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL PROCESSES

David S. Wishart

PHYSIOLOGICAL REVIEWS (2019)

Article Genetics & Heredity

The mutational footprints of cancer therapies

Oriol Pich et al.

NATURE GENETICS (2019)

Review Cell Biology

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Martha A. Sanchez-Rodriguez et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Immunology

Niches for Hematopoietic Stem Cells and Their Progeny

Qiaozhi Wei et al.

IMMUNITY (2018)

Review Biochemistry & Molecular Biology

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

Jose Pedro Castro et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

Bebiana C. Sousa et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Cell Biology

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Ilaria Marrocco et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Biotechnology & Applied Microbiology

Emerging applications of metabolomics in drug discovery and precision medicine

David S. Wishart

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Biochemistry & Molecular Biology

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Yun-Hee Youm et al.

NATURE MEDICINE (2015)

Review Cell Biology

Metabolic requirements for the maintenance of self-renewing stem cells

Keisuke Ito et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Oncology

Redox molecules and cancer prevention: The importance of understanding the role of the antioxidant network

Mauro Serafini et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2006)