4.7 Article

Discovery of triphenylphosphonium (TPP)-conjugated N-(1,1′-biphenyl)-2-yl aliphatic amides as excellent fungicidal candidates

Related references

Note: Only part of the references are listed.
Review Agriculture, Multidisciplinary

Comprehensive Overview of Carboxamide Derivatives as Succinate Dehydrogenase Inhibitors

Bo Luo et al.

Summary: This review summarizes the importance of carboxamide derivatives as SDHIs and the structure-activity relationships of their antifungal activities. It also introduces the reasons behind SDHIs resistance and potential solutions, as well as prospects the development trend of SDHIs fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Agriculture, Multidisciplinary

Fungicidal Action of the Triphenylphosphonium-Driven Succinate Dehydrogenase Inhibitors Is Mediated by Reactive Oxygen Species and Suggests an Effective Resistance Management Strategy

Jiayao Wang et al.

Summary: The study found that the newly synthesized antifungal compound 2c acts on mitochondria through targeted action, giving it a broader spectrum of fungicidal activity and enhanced efficacy. This change makes it difficult for fungi to develop resistance to it, which is significant for managing the increasing field resistance to SDHI fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Review Geriatrics & Gerontology

Mitochondria-targeted senotherapeutic interventions

Mehmet Can Atayik et al.

Summary: Healthy aging is a delicate balance, with age-related disorders playing a significant role in making life difficult with aging. Developing senotherapeutic strategies, particularly targeting mitochondrial dysfunction, could provide effective solutions for age-related disorders. The interplay between mitochondrial dysfunction and the development of senescence-associated secretory phenotype (SASP) is closely linked to weakened immunity, a common phenomenon in aging. Targeting senescent cells with senolytics or suppressing their SASP secretions with senomorphics/senostatics could potentially extend both health and lifespan.

BIOGERONTOLOGY (2022)

Article Biochemistry & Molecular Biology

The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Shuqi Li et al.

Summary: Succinate dehydrogenase inhibitors (SDHIs) are a rapidly growing class of new fungicides with high activity and a broad spectrum. By inhibiting the activity of succinate dehydrogenase, they disrupt mitochondrial respiration and kill pathogenic fungi, making them popular among major pesticide companies worldwide for research and development.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors

Bin Yu et al.

Summary: In this study, 43 novel pyrazole-aromatic containing carboxamides were designed and synthesized, showing promising antifungal activities against various fungi. Compound 11ea exhibited the most significant in vitro activity against R. cerealis, potentially sharing the same target SDH with the positive control thifluzamide.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines

James E. Gillespie et al.

Summary: The method utilizes noncovalent interactions to control positional selectivity in radical reactions, enabling direct access to ortho-phenylenediamines through amination, crucial for the synthesis of medicinally relevant compounds.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Biochemistry & Molecular Biology

Activity of a SDHI fungicide penflufen and the characterization of natural-resistance in Fusarium fujikuroi

Yanan Sun et al.

Summary: The novel succinate dehydrogenase inhibitor fungicide penflufen showed good bioactivity against F. fujikuroi but weak activity against other fungi, indicating its potential in controlling the disease. Natural resistance to penflufen was observed among F. fujikuroi isolates, with no cross-resistance to commonly used fungicides detected. Mutation analysis identified five different point mutations in resistant isolates, providing insights into possible resistance mechanisms.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2021)

Review Chemistry, Medicinal

Triphenylphosphonium (TPP)-Based Antioxidants: A New Perspective on Antioxidant Design

Jiayao Y. Wang et al.

CHEMMEDCHEM (2020)

Article Agriculture, Multidisciplinary

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Xiao-Dan Yin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

Giovanna Cenini et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Chemistry, Medicinal

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nghi Nguyen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biotechnology & Applied Microbiology

Mitochondria as a therapeutic target for common pathologies

Michael P. Murphy et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Agriculture, Multidisciplinary

Design, Synthesis, Fungicidal Activity, and Unexpected Docking Model of the First Chiral Boscalid Analogues Containing Oxazolines

Shengkun Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)

Review Chemistry, Multidisciplinary

Mitochondrial biology, targets, and drug delivery

Lara Milane et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Biochemistry & Molecular Biology

Baseline sensitivity and resistance risk assessmemt of Rhizoctonia cerealis to thifluzamide, a succinate dehydrogenase inhibitor

Yu Zhang et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2015)

Article Chemistry, Medicinal

Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity

Daqian Zhu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Design, synthesis and antifungal/insecticidal evaluation of novel nicotinamide derivatives

Fang Wen et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2010)