Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium

Background: Responsive neurostimulation (RNS), a closed-loop intracranial electrical stimulation system, is a palliative surgical option for patients with drug-resistant epilepsy (DRE). RNS is approved by the US Food and Drug Administration for patients aged >= 18 years with pharmacoresistant partial seizures. The published experience of RNS in children is limited.Methods: This is a combined prospective and retrospective study of patients aged <= 18 years undergoing RNS placement. Patients were identified from the multicenter Pediatric Epilepsy Research Consortium Surgery Registry from January 2018 to December 2021, and additional data relevant to this study were retrospectively collected and analyzed.Results: Fifty-six patients received RNS during the study period. The mean age at implantation was 14.9 years; the mean duration of epilepsy, 8.1 years; and the mean number of previously trialed anti-seizure medications, 4.2. Five patients (9%) previously trialed dietary therapy, and 19 patients (34%) underwent prior surgery. Most patients (70%) underwent invasive electroencephalography evaluation before RNS implantation. Complications occurred in three patients (5.3%) including malpositioned leads or transient weakness. Follow-up (mean 11.7 months) was available for 55 patients (one lost), and four were seizure-free with RNS off. Outcome analysis of stimulation efficacy was available for 51 patients: 33 patients (65%) were responders (>= 50% reduction in seizure frequency), including five patients (10%) who were seizure free at follow-up.Conclusions: For young patients with focal DRE who are not candidates for surgical resection, neuro-modulation should be considered. Although RNS is off-label for patients aged <18 years, this multicenter study suggests that it is a safe and effective palliative option for children with focal DRE.(c) 2023 Elsevier Inc. All rights reserved.

Automated summary

Responsive neurostimulation (RNS) is a palliative surgical option for patients with drug-resistant epilepsy (DRE). While RNS has been proven effective for adults, its application in children with focal DRE is limited. This study suggests that RNS is a safe and effective palliative option for children with focal DRE.