4.5 Review

The chick embryo chorioallantoic membrane patient-derived xenograft (PDX) model

Journal

PATHOLOGY RESEARCH AND PRACTICE
Volume 243, Issue -, Pages -

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154367

Keywords

Chorioallantoic membrane; Metastasis; Patient-derived xenografts; Tumor growth

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The chick embryo chorioallantoic membrane (CAM) is a fusion of the chorion with the vascularized allantoic membrane, performing multiple functions during embryonic development. It is a widely used model for studying angiogenesis, tumor growth, and drug efficacy. This review article focuses on the effects of patient-derived xenografts (PDX) on the CAM, highlighting the use of CAM for pharmacological screenings and immune response-free transplantation.
The chick embryo chorioallantoic membrane (CAM) CAM is an extraembryonic membrane generated by the fusion of the chorion with the vascularized allantoic membrane. It performs multiple functions during embryonic development, including respiration, calcium transport from the eggshell, acid-base homeostasis, and ion/water reabsorption from the allantoic fluid. The CAM is a widely used model for the study of angiogenesis, anti-angiogenesis, tumor growth, and metastasis as well as drug efficacy. Ethical approval is omitted if experi-ments are terminated at embryonic day 14 in most countries, facilitating screenings of pharmacological physics-based therapies with high reproducibility at large scales supporting the 3Rs principle. Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species without immune response. This review article is focused on the analysis of the literature and personal data concerning the effects of patient-derived xenografts (PDX) on the CAM.

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