Role of MAGI2-AS3 in malignant and non-malignant disorders

MAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) transcribed from a locus on 7q21.11. This lncRNA has been described to be abnormally expressed in a variety of malignancies in correlation with many clinical characteristics. Moreover, it might participate in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 can serve as a molecular sponge for miR-142-3p, miR-424-5p, miR-15b, miR-233, miR-452-5p, miR-629-5p, miR-25, miR-155, miR-23a-3p, miR-519c-3p, miR-374b-5p, miR-374a, miR-31-5p, miR-3163, miR-525-5p, miR-15-5p, miR-374a-5p, miR-374b-5p, miR-218-5p, miR-141-3p and miR-200a-3p to regulate expression of their mRNA targets. The current review summarizes the role of MAGI2-AS3 in different disorders to highlight its importance in their pathophysiology.

Automated summary

MAGI2-AS3 is a long non-coding RNA that is abnormally expressed in various malignancies and is associated with multiple clinical characteristics. It may play a role in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease, and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 acts as a molecular sponge for multiple miRNAs to regulate the expression of their mRNA targets. This review highlights the importance of MAGI2-AS3 in different disorders.