4.5 Article

Deciphering the role of Hippo pathway in lung cancer

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway

Jiaqi Jin et al.

Summary: This study reveals that oxidative stress promotes acetylation of MOB1, a key component of the Hippo pathway, by inhibiting the degradation of acetyltransferase CBP. Acetylated MOB1 activates the Hippo pathway and serves as a better predictor for overall survival in patients with non-small cell lung cancer.

NUCLEIC ACIDS RESEARCH (2022)

Article Biotechnology & Applied Microbiology

Circular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p

Jianming Mo et al.

Summary: In this study, it was found that circ_0067741 inhibits the proliferation, migration, invasion, and angiogenesis of LUAD cells by regulating the miR-183-5p/LATS1/Hippo/YAP pathway and promoting apoptosis. Therefore, the circ_0067741/miR-183-5p/LATS1 axis may serve as a potential target for early diagnosis and targeted treatment of LUAD.

BIOENGINEERED (2022)

Article Medicine, Research & Experimental

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling

Chuan Xu et al.

Summary: Signal regulatory protein gamma (SIRP gamma) determines the properties and immune evasiveness of cancer stem-like cells (CSLCs) in a small population of lung adenocarcinoma (LUAD) cancer cells. SIRP gamma activates the Hippo/YAP signaling pathway to release cytokines and stimulate CD47 expression in tumor cells, inhibiting their phagocytosis. Targeting SIRP gamma can inhibit CSLC phenotypes and promote tumor phagocytosis, making it an immune and CSLC-targeting strategy for lung cancer therapy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Cell Biology

Hypoxic bone marrow mesenchymal cell-extracellular vesicles containing miR-328-3p promote lung cancer progression via the NF2-mediated Hippo axis

Xi Liu et al.

Summary: The study demonstrated that EVs derived from hypoxic bone marrow mesenchymal cells can deliver miR-328-3p to lung cancer cells, promoting cancer cell proliferation, invasion, and migration by targeting the NF2 gene to inhibit the Hippo pathway. This ultimately leads to the occurrence and progression of lung cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Cell Biology

Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling

Kang-Yun Lee et al.

Summary: CD109 is upregulated in metastatic lung adenocarcinoma cells, correlated with EMT traits in patients, and crucial for EMT gene expressions, tumor invasiveness, and cancer stemness properties. The elevation of CD109 is also associated with YAP signature in metastatic lung cancer cells, and YAP activation participates in CD109-induced EMT gene expressions and tumor invasiveness.

CELLS (2021)

Article Environmental Sciences

Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ

Yuzhen Zheng et al.

Summary: Curcumin can attenuate the stemness of lung cancer cells by promoting TAZ protein degradation, reducing the expression of stem cell markers, and enhancing cisplatin sensitivity. It also activates the Hippo pathway, leading to a decrease in cancer stem cell function and an increase in cancer stem cell differentiation ability.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Oncology

miR-582-5p Is a Tumor Suppressor microRNA Targeting the Hippo-YAP/TAZ Signaling Pathway in Non-Small Cell Lung Cancer

Bowen Zhu et al.

Summary: The study identified miR-582-5p as a post-transcriptional regulator of the Hippo-YAP/TAZ signaling pathway in NSCLC cells, inhibiting YAP/TAZ signaling by targeting NCKAP1 and PIP5K1C. The findings highlight the potential therapeutic value of restoring miR-582-5p expression in the treatment of lung cancer driven by YAP/TAZ.

CANCERS (2021)

Article Cell Biology

LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer

Bowen Zhu et al.

Summary: Long non-coding RNAs (lncRNAs) play critical roles in development and carcinogenesis, while the Hippo-YAP/TAZ signaling pathway is essential for organ size control and often dysregulated in cancers. SFTA1P was identified as a novel transcriptional target and positive feedback regulator of YAP/TAZ signaling, with knockdown inhibiting proliferation and inducing cell death in NSCLC cell lines. Mechanistically, SFTA1P knockdown decreased TAZ protein abundance, affecting the expression of YAP/TAZ transcriptional targets, suggesting its potential role in lncRNA-based therapies against YAP/TAZ-driven cancers.

CELL DEATH DISCOVERY (2021)

Article Cell Biology

WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression

Qiang Han et al.

Summary: WBP2 is highly expressed in lung cancer and correlates with clinical features and prognosis. Functional experiments demonstrate that WBP2 promotes proliferation and invasion of lung cancer cells. WBP2 inhibits Hippo pathway activity by competitively binding to WWC3 and LATS1, leading to YAP nuclear translocation.

CELL DEATH & DISEASE (2021)

Article Medicine, Research & Experimental

Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro

Gaochenxi Zhang et al.

Summary: The study revealed that the aqueous extract of Taxus chinensis var. mairei (TC) has potential anti-tumor effects in promoting apoptosis in non-small cell lung cancer (NSCLC) cells via the ATF3-Hippo-YAP pathway. AETC showed minimal inhibitory effects on normal cells and mice, indicating its potential as a promising adjuvant for NSCLC therapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

KCTD11 inhibits progression of lung cancer by binding to β-catenin to regulate the activity of the Wnt and Hippo pathways

Man Yang et al.

Summary: KCTD11 is under-expressed in lung cancer tissues and cells, negatively correlated with differentiation, TNM stage, and lymph node metastasis, and associated with poor prognosis. Overexpression of KCTD11 inhibits proliferation and migration of lung cancer cells by suppressing the Wnt pathway, activating the Hippo pathway, and inhibiting the EMT process.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Oncology

Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non-small cell lung cancer

Yijun Zhang et al.

Summary: The study revealed that high expression of INHBA in clinical NSCLC is associated with advanced tumor stage and poor prognosis, and it can enhance the invasive abilities of NSCLC by modulating the Hippo pathway.

MOLECULAR MEDICINE REPORTS (2021)

Article Biochemistry & Molecular Biology

MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway

Wenbin Liu et al.

Summary: MPDZ is downregulated in lung cancer tissues, negatively correlated with DNA hypermethylation, and reduced expression predicts poor prognosis. MPDZ functions as a tumor suppressor by inhibiting cell proliferation, migration, and invasion both in vitro and in vivo.

ONCOGENE (2021)

Article Pharmacology & Pharmacy

The novel FAT4 activator jujuboside A suppresses NSCLC tumorigenesis by activating HIPPO signaling and inhibiting YAP nuclear translocation

Wensheng Wang et al.

Summary: The study demonstrates that Jujuboside A (JUA) has anti-lung cancer activity by activating the FAT4-HIPPO-YAP signaling pathway to suppress tumorigenesis in non-small cell lung cancer (NSCLC).

PHARMACOLOGICAL RESEARCH (2021)

Article Oncology

Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway

Jing Chen et al.

Summary: The research revealed that LUAD cells induced M2 polarization of TAMs by transporting miR-19b-3p via exosomes, activating STAT3 pathway to promote tumor metastasis. The interactive communication between LUAD cells and TAMs through exchange of exosomal miR-19b-3p and LINC00273 was elucidated, proving the pro-metastatic effect of this interchange. These findings offer a new perspective for developing LUAD treatment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Oncology

CDK5 Activates Hippo Signaling to Confer Resistance to Radiation Therapy Via Upregulating TAZ in Lung Cancer

Yulan Zeng et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Article Medicine, Research & Experimental

Distinct transcriptional programs of SOX2 in different types of small cell lung cancers

Yuki Tenjin et al.

LABORATORY INVESTIGATION (2020)

Article Medicine, Research & Experimental

Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway

Jiayu Zho et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Medicine, Research & Experimental

Analysis of the role of the Hippo pathway in cancer

Yanyan Han

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Article Engineering, Environmental

Dysfunction of the Hippo-Yap Pathway Drives Lung Cancer Metastasis Induced by 1-Nitropyrene through Adhesion Molecular Activation

Rui Gao et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2019)

Review Cell Biology

Hippo Signaling in Cancer: Lessons From Drosophila Models

Kirti Snigdha et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

The Hippo Pathway: Biology and Pathophysiology

Shenghong Ma et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Oncology

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

Helena J. Janse van Rensburg et al.

CANCER RESEARCH (2018)

Article Biotechnology & Applied Microbiology

WWC3 inhibits epithelial-mesenchymal transition of lung cancer by activating Hippo-YAP signaling

Qiang Han et al.

ONCOTARGETS AND THERAPY (2018)

Article Oncology

A Plasma Long Noncoding RNA Signature for Early Detection of Lung Cancer

Yanli Lin et al.

TRANSLATIONAL ONCOLOGY (2018)

Article Cell Biology

Long noncoding RNA CASC9/miR-519d/STAT3 positive feedback loop facilitate the glioma tumourigenesis

Hongjiang Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Review Pharmacology & Pharmacy

The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications

Seong Lin Teoh et al.

CURRENT DRUG TARGETS (2017)

Article Biochemistry & Molecular Biology

Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance

Jeong Eun Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Oncology

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

Nicholas Nelson et al.

ONCOTARGET (2016)

Review Biochemistry & Molecular Biology

The regulation and function of YAP transcription co-activator

Chu Zhu et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)

Article Cell Biology

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

Krishna P. L. Bhat et al.

GENES & DEVELOPMENT (2011)

Article Oncology

Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene

Chad A. Hall et al.

CANCER RESEARCH (2010)