Dysregulation of non-coding RNAs in Wilms tumor

Article Biotechnology & Applied Microbiology

CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ABL proto-oncogene 2 axis

Jiaju Xu et al.

Summary: The dysregulation of circSLC7A6 promotes the progression of Wilms' tumor by upregulating ABL2 expression through inhibiting miR-107 expression.

BIOENGINEERED (2022)

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Article Oncology

LncRNA SNHG6 Promotes Wilms' Tumor Progression Through Regulating miR-429/FRS2 Axis

Yingjie Wang et al.

Summary: In Wilms' tumor, elevated expression of SNHG6 accelerates tumor progression by regulating the miR-429/FRS2 signaling pathway, promoting cell proliferation and glycolysis while inhibiting apoptosis.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2021)

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Article Cell Biology

Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2

Shibo Zhu et al.

Summary: Nephroblastoma, a pediatric kidney cancer, is associated with abnormal expression of lncRNA MYLK-AS1, which promotes cell proliferation and cycle distribution through the TCF7L2/CCNE1 signaling pathway. Silencing of MYLK-AS1 inhibits the tumorigenic ability of nephroblastoma cells in vivo, highlighting its potential as a biomarker for early detection and treatment.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Cell Biology

MiR-200a with CDC7 as a direct target declines cell viability and promotes cell apoptosis in Wilm's tumor via Wnt/β-catenin signaling pathway

Xiu-Ling Liang et al.

Summary: MiR-200a plays a crucial role in the malignant progression of tumors, with potential implications for Wilm's tumor. Lower expression of miR-200a in Wilm's tumor tissues and cells is associated with poorer outcomes and increased cell death. Additionally, miR-200a targets and inhibits CDC7 in Wilm's tumor cells, impacting cell viability and apoptosis. Further research into the miR-200a/CDC7 axis and its effects on the Wnt/beta-catenin signaling pathway provide a foundation for potential targeted molecular therapies for Wilm's tumor.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2

Qiang Yu et al.

Summary: Studies have shown that miR-378c is downregulated in Wilms tumor, and overexpression of miR-378c can inhibit tumor cell growth and metastasis, even inhibiting tumor development in xenograft models. MiR-378c exerts its function in Wilms tumor by directly targeting CAMKK2 gene.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Biochemistry & Molecular Biology

Mechanistic Insight Into the Regulation of Immune-Related Genes Expression in Autism Spectrum Disorder

Hani Sabaie et al.

Summary: Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by impairment in verbal and non-verbal interactions, defects in social interactions, stereotypic behaviors, and restricted interests. Despite efforts to understand its pathophysiology, the exact etiology remains unresolved. This study used a bioinformatics approach to analyze the role of long non-coding RNA (lncRNA)-associated competing endogenous RNAs (ceRNAs) in peripheral blood samples of ASD patients, providing insights into the molecular regulatory processes involved in ASD.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Cell Biology

CircCDYL Acts as a Tumor Suppressor in Wilms' Tumor by Targeting miR-145-5p

Rui Zhou et al.

Summary: Circular RNA CDYL (circCDYL) was downregulated in Wilms' tumor tissue compared to adjacent non-tumor tissue, and its upregulation inhibited cell proliferation, migration, and invasion by acting as a miRNA sponge to regulate the miR-145-5p/TJP1 axis. This study suggests circCDYL as a potential novel biomarker and therapeutic target for Wilms' tumor treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

MicroRNA-215-5p Inhibits the Proliferation and Migration of Wilm's Tumor Cells by Targeting CRK

Li Wang et al.

Summary: The study demonstrated that miR-215-5p could suppress the proliferation and migration of Wilm's tumor cells by regulating the expression of CRK, providing new insights into molecular targeted therapy for Wilm's tumor.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

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Article Pathology