Dysregulation of non-coding RNAs in Wilms tumor

Wilms tumor (WT) as the most frequent pediatric tumor of kidney has been shown to be associated with dys-regulation of non-coding RNAs. miR-200c, miR-155-5p, miR-1180, miR-22-3p, miR-483-5p, miR-140-5p, miR-92a-3p, miR-483-3p, miR-572, miR-539 and miR-613 are among dysregulated miRNAs in this tumor. Moreover, a number of long non-coding RNAs such as CRNDE, XIST, SNHG6, MEG3, LINC00667, MEG8, DLGAP1-AS2 and SOX21-AS1 have been shown to be dysregulated in WT. Finally, distinct studies have reported down-regulation of circCDYL and up-regulation of circ0093740 and circSLC7A6 in this tumor. Dysregulation of these transcripts represents a new avenue for identification of the pathetiology of this pediatric tumor as well as design of targeted therapies.

Automated summary

Wilms tumor, the most common pediatric kidney tumor, is associated with dysregulation of non-coding RNAs. Dysregulated miRNAs such as miR-200c, miR-155-5p, miR-1180, miR-22-3p, miR-483-5p, miR-140-5p, miR-92a-3p, miR-483-3p, miR-572, miR-539, and miR-613, as well as dysregulated long non-coding RNAs including CRNDE, XIST, SNHG6, MEG3, LINC00667, MEG8, DLGAP1-AS2, and SOX21-AS1, have been identified in this tumor. Additionally, circCDYL is down-regulated, while circ0093740 and circSLC7A6 are up-regulated in Wilms tumor. These dysregulated transcripts offer new insights into understanding the pathogenesis and developing targeted therapies for this pediatric tumor.