4.5 Article

Real-Time Intraoperative Detection of Margins for Oral Cavity Squamous Cell Carcinoma

Journal

OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Volume -, Issue -, Pages -

Publisher

WILEY
DOI: 10.1002/ohn.397

Keywords

dynamic optical contrast imaging; margin detection; oral cancer

Ask authors/readers for more resources

Obtaining negative surgical cancer margins is crucial for long-term survival in oral cavity squamous cell carcinoma patients. The use of dynamic optical contrast imaging (DOCI) provides a real-time intraoperative tool that can quickly and accurately distinguish cancer from healthy tissues, improving surgical outcomes and overall survival.
Obtaining negative surgical cancer margins is the strongest predictor for the long-term survival of oral cavity squamous cell carcinoma patients. To verify that the tumor has been completely removed, surgeons rely on pathologic evaluation of frozen sections to determine surgical margins, which can be time-consuming and subjective. Herein, we detail the real-time intraoperative use of dynamic optical contrast imaging (DOCI), a novel imaging modality that rapidly distinguishes head and neck cancer from healthy adjacent tissues based on fluorescence decay information from spectral bands in the UV-VIS range. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology (p < .05). DOCI delivers a clinically relevant tool that may better inform and drive precision surgery, directly impacting surgical outcomes and improving overall survival for our patients.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available