Journal
ORGANIC LETTERS
Volume 25, Issue 15, Pages 2564-2564Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00293
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Through genome mining, the discovery and characterization of atypical compounds, cinnamomycin A-D, with selective antiproliferative activity. The biosynthetic pathway of cinnamomycins was proposed based on genetic manipulation, enzymatic reaction, and precursor feeding.
3,5-Dihydroxybenzoic acid (3,5-DHBA), biosynthe-sized by type III PKS and tailoring enzymes, is an unconventional starter unit for bacterial type I PKS. Genome mining of 3,5-DHBA-specific biosynthetic gene clusters could lead to discovering new type I/type III PKS hybrids. Herein, we report the discovery and characterization of atypical compounds, namely cinnamomycin A- D, exhibiting selective antiproliferative activity. The biosynthetic pathway of cinnamomycins was proposed based on genetic manipulation, enzymatic reaction, and precursor feeding.
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