Amide-Directed, Rhodium-Catalyzed Enantioselective Hydrosilylation of Unactivated Internal Alkenes

Despite the recent advances made in the area of asymmetric hydrosilylation, metal-catalyzed enantioselective hydrosilylation of unactivated internal alkenes remains a challenge. Here, we report a rhodium-catalyzed enantioselective hydrosilylation of unactivated internal alkenes bearing a polar group. The coordination assistance by an amide group enables the hydrosilylation to occur with high regio-and enantioselectivity.

Automated summary

Despite recent progress in asymmetric hydrosilylation, achieving metal-catalyzed enantioselective hydrosilylation of unactivated internal alkenes remains challenging. In this study, we demonstrate a rhodium-catalyzed enantioselective hydrosilylation of unactivated internal alkenes bearing a polar group. The coordination assistance provided by an amide group enables the reaction to proceed with high regio- and enantioselectivity.