Copper-Mediated Deconstructive Ring Cleavage of Cyclic Thioethers with Boron Compounds

The deconstructive ring cleavage of cyclic thioethers is achieved through a Chan-Lam type process with boron compounds. The sequential hydroboration/ring cleavage process from alkynes offered a new route to the preparation of vinyl sulfides based on the developed conditions. Further exploration has demonstrated the versatility of nucleophiles, delivering various functionalized sulfides featuring linear frameworks.

Automated summary

The deconstructive ring cleavage of cyclic thioethers is achieved using boron compounds. The sequential hydroboration/ring cleavage process enables the preparation of vinyl sulfides via newly developed conditions. Further exploration demonstrates the versatility of nucleophiles, leading to various functionalized sulfides with linear frameworks.