Related references
Note: Only part of the references are listed.Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles: convenient synthesis of gemigliptin
Zhi-Peng Bao et al.
SCIENCE CHINA-CHEMISTRY (2023)
Fluorine-containing drugs approved by the FDA in 2021
Jingrui He et al.
CHINESE CHEMICAL LETTERS (2023)
Nickel-Catalyzed anti-Markovnikov Hydrodifluoroalkylation of Unactivated Alkenes
Li-Ming Yin et al.
ORGANIC LETTERS (2022)
Photocatalytic Reductive Olefin Hydrodifluoroalkylation Enabled by Tertiary Amine Reductants Compatible with Complex Systems
Jonathan D. Ellefsen et al.
JOURNAL OF ORGANIC CHEMISTRY (2022)
Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer
Zhi-Qi Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
Catalytic Hydrodifluoroalkylation of Unactivated Olefins
Wen-Jun Yue et al.
ORGANIC LETTERS (2022)
Fluorinated Cycloalkyl Building Blocks for Drug Discovery
Oleksandr O. Grygorenko et al.
CHEMMEDCHEM (2022)
Remote Nucleophilic Substitution at a C(sp3)-H Bond of a-Bromocarboxamides via 1,4-Hydrogen Atom Transfer To Access N-Acyl-N,O-acetal Compounds
Daisuke Shimizu et al.
ORGANIC LETTERS (2022)
Visible-Light-Induced Metal-Free Decarboxylative Perfluoroalkylation of Aryl Acrylic Acids
Mo Yu et al.
ORGANIC LETTERS (2022)
Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates
Zhi-Peng Bao et al.
CHEMICAL SCIENCE (2022)
State of knowledge in photoredox-catalysed direct difluoromethylation
Jiaxu Feng et al.
ORGANIC CHEMISTRY FRONTIERS (2022)
Radical-Promoted Distal C-H Functionalization of C(sp3) Centers with Fluorinated Moieties
Enzo Nobile et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Synthesis of Fluoro-, Monofluoromethyl-, Difluoromethyl-, and Trifluoromethyl-Substituted Three-Membered Rings
Jonathan Decaens et al.
CHEMISTRY-A EUROPEAN JOURNAL (2021)
Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H
Jun Yang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Recent Advances in Synthesis of Difluoromethylene Phosphonates for Biological Applications
Michael Shevchuk et al.
ADVANCED SYNTHESIS & CATALYSIS (2021)
Sequential C-F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts
You-Jie Yu et al.
SCIENCE (2021)
Late-stage difluoromethylation: concepts, developments and perspective
Jeroen B. I. Sap et al.
CHEMICAL SOCIETY REVIEWS (2021)
Visible light photoredox-catalysed remote C-H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT)
Weisi Guo et al.
CHEMICAL SOCIETY REVIEWS (2021)
Photoinduced Decarboxylative Amino-Fluoroalkylation of Maleic Anhydride
Youwen Sun et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Polar Organofluorine Substituents: Multivicinal Fluorines on Alkyl Chains and Alicyclic Rings
David O'Hagan
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Chen's Reagent: A Versatile Reagent for Trifluoromethylation, Difluoromethylenation, and Difluoroalkylation in Organic Synthesis†
Qiqiang Xie et al.
CHINESE JOURNAL OF CHEMISTRY (2020)
Utilizing the CF2H moiety as a H-bond-donating group in drug discovery
Yossi Zafrani et al.
FUTURE MEDICINAL CHEMISTRY (2020)
Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)
Louise Ruyet et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2020)
Radical-Mediated Remote Functional Group Migration
Xinxin Wu et al.
ACCOUNTS OF CHEMICAL RESEARCH (2020)
Visible-Light Photoredox-Catalyzed Remote Difunctionalizing Carboxylation of Unactivated Alkenes with CO2
Lei Song et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides
Chuan-Hua Qu et al.
JOURNAL OF ORGANIC CHEMISTRY (2020)
C-H functionalization reactions enabled by hydrogen atom transfer to carbon-centered radicals
Sumon Sarkar et al.
CHEMICAL SCIENCE (2020)
Synthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides
Chengwen Li et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2020)
Photocatalytic hydrogen atom transfer: the philosopher's stone for late-stage functionalization?
Luca Capaldo et al.
GREEN CHEMISTRY (2020)
Promising reagents for difluoroalkylation
Dao-Qing Dong et al.
ORGANIC CHEMISTRY FRONTIERS (2020)
Visible light-mediated atom transfer radical addition to styrene: base controlled selective (phenylsulfonyl)difluoromethylation
Jie Sheng et al.
ORGANIC CHEMISTRY FRONTIERS (2020)
Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Claudio F. Meyer et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?
Yossi Zafrani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Versatile Ru-Photoredox-Catalyzed Functionalization of Dehydro-Amino Acids and Peptides
Tobias Brandhofer et al.
CHEMCATCHEM (2019)
Copper-Catalyzed, Chloroamide-Directed Benzylic C-H Difluoromethylation
Xiaojun Zeng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Photoredox-Catalyzed Remote Difunctionalizations of Alkenes To Synthesize Fluoroalkyl Ketones with Dimethyl Sulfoxide as the Oxidant
Lixin Li et al.
ORGANIC LETTERS (2019)
Progress in Difluoroalkylation of Organic Substrates by Visible Light Photoredox Catalysis
Agostinho Lemos et al.
ADVANCED SYNTHESIS & CATALYSIS (2019)
Visible-light-induced radical hydrodifluoromethylation of alkenes
Jiao Yu et al.
ORGANIC CHEMISTRY FRONTIERS (2019)
Catalytic cascade reactions by radical relay
Huan-Ming Huang et al.
CHEMICAL SOCIETY REVIEWS (2019)
Recent progress in photochemical radical di- and mono-fluoromethylation
Takashi Koike et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2019)
Use of a benzyl ether as a traceless hydrogen donor in the anti-Markovnikov hydrofunctionalization of alkenes with xanthates
Hirohito Hayashi et al.
CHEMICAL COMMUNICATIONS (2018)
Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds
Jian Zhang et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2018)
Remote C-H Functionalization via Selective Hydrogen Atom Transfer
Leah M. Stateman et al.
SYNTHESIS-STUTTGART (2018)
Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes
Wei Shu et al.
ACS CATALYSIS (2018)
Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides
Zhang Feng et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Applications of Radical Carbonylation and Amine Addition Chemistry: 1,4-Hydrogen Transfer of 1-Hydroxylallyl Radicals
Hiroshi Matsubara et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation
Na Wang et al.
ORGANIC CHEMISTRY FRONTIERS (2018)
Difluoromethyl Bioisostere: Examining the Lipophilic Hydrogen Bond Donor Concept
Yossi Zafrani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester
Shuhei Sumino et al.
JOURNAL OF ORGANIC CHEMISTRY (2017)
CF2H, a Hydrogen Bond Donor
Chanan D. Sessler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Copper-Catalyzed C-H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes
Xiaoyang Wang et al.
ORGANIC LETTERS (2017)
Organic Dye-Catalyzed Atom Transfer Radical Addition Elimination (ATRE) Reaction for the Synthesis of Perfluoroalkylated Alkenes
Deo Prakash Tiwari et al.
ORGANIC LETTERS (2017)
Silicon-Based Reagents for Difluoromethylation and Difluoromethylenation Reactions
Sankarganesh Krishnamoorthy et al.
SYNTHESIS-STUTTGART (2017)
Visible-light-induced dearomative spirocyclization of N-benzylacrylamides toward perfluorinated azaspirocyclic cyclohexadienones
Shi Tang et al.
TETRAHEDRON LETTERS (2017)
Metal-Catalyzed Direct Difluoromethylation Reactions
Jian Rong et al.
ASIAN JOURNAL OF ORGANIC CHEMISTRY (2017)
Phosphine-catalyzed remote α-C-H bond activation of alcohols or amines triggered by the radical trifluoromethylation of alkenes: reaction development and mechanistic insights
Lei Li et al.
ORGANIC CHEMISTRY FRONTIERS (2017)
Difluoromethylation Reactions of Organic Compounds
Damian E. Yerien et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
Anti-Markovnikov Hydrofunctionalization of Alkenes: Use of a Benzyl Group as a Traceless Redox-Active Hydrogen Donor
Geoffroy Herve Lonca et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide
Qing-Yu Lin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou et al.
CHEMICAL REVIEWS (2016)
Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones
Zuxiao Zhang et al.
ORGANIC LETTERS (2016)
Phosphine-Catalyzed Remote beta-C-H Functionalization of Amines Triggered by Trifluoromethylation of Alkenes: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles
Peng Yu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon-Heteroatom/Carbon Bonds
Lin Huang et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers
Marie-Charlotte Belhomme et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Metal-Free Direct 1,6-and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes
Lin Huang et al.
ORGANIC LETTERS (2015)
Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-Lactam
Lin Huang et al.
ACS CATALYSIS (2015)
Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene
Peng Yu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Selective difluoroalkylation of alkenes by using visible light photoredox catalysis
Chunghyeon Yu et al.
CHEMICAL COMMUNICATIONS (2014)
An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature
Guobin Ma et al.
CHEMICAL COMMUNICATIONS (2014)
1,n-Hydrogen-Atom Transfer (HAT) Reactions in Which n ≠ 5: An Updated Inventory
Malek Nechab et al.
CHEMISTRY-A EUROPEAN JOURNAL (2014)
Copper-Catalyzed Intramolecular Trifluoromethylation of N-Benzylacrylamides Coupled with Dearomatization: Access to CF3-Containing 2-Azaspiro[4.5]decanes
Guifang Han et al.
ORGANIC LETTERS (2014)
Photoinduced radical hydroperfluoroalkylation and the synthesis of fluorinated amino acids and peptides
Tomoko Yajima et al.
JOURNAL OF FLUORINE CHEMISTRY (2013)
Copper Catalyzed β-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C-H Functionalization
Marie-Charlotte Belhomme et al.
ORGANIC LETTERS (2013)
On the Interpretation of Deuterium Kinetic Isotope Effects in C?H Bond Functionalizations by Transition-Metal Complexes
Eric M. Simmons et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Understanding Hydrogen Atom Transfer: From Bond Strengths to Marcus Theory
James M. Mayer
ACCOUNTS OF CHEMICAL RESEARCH (2011)
Understanding organofluorine chemistry. An introduction to the C-F bond
David O'Hagan
CHEMICAL SOCIETY REVIEWS (2008)
Fluorine in medicinal chemistry
Sophie Purser et al.
CHEMICAL SOCIETY REVIEWS (2008)
Fluorine in pharmaceuticals:: Looking beyond intuition
Klaus Mueller et al.
SCIENCE (2007)
Reactions of ethyl bromodifluoroacetate in the presence of copper powder
K Sato et al.
JOURNAL OF FLUORINE CHEMISTRY (2004)