Journal
ORGANIC LETTERS
Volume 25, Issue 20, Pages 3670-3675Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01056
Keywords
-
Categories
Ask authors/readers for more resources
A stereocontrolled electrophilic amination approach was employed for the synthesis of α-aminoketone derivatives with less accessible α-tetrasubstituted stereocenters. Stereospecific α-deprotonation of ketimines followed by nucleophilic attack of azodicarboxylic derivatives afforded α-aminated products in high yields with excellent stereoselectivities.
A stereocontrolled electrophilicamination of alpha-branched N-tert-butanesulfinyl ketimines was developedto construct alpha-aminoketone derivatives containing less accessible alpha-tetrasubstituted stereocenters. Stereospecific alpha-deprotonationof ketimines with potassium tert-butoxide gave stereodefinedmetalloenamine intermediates that could act as nucleophiles to attackazodicarboxylic derivatives, affording alpha-aminated products inhigh yields with excellent stereoselectivities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available