Journal
ORGANIC LETTERS
Volume 25, Issue 22, Pages 4214-4218Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01564
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Cesium carbonate-mediated stereoselective anomeric O-alkylation of a 2N,3O-oxazolidinone-protected d-mannosamine with sugar-derived primary or secondary alkyltriflates afforded the corresponding 2-amino-2-deoxy-beta-d-mannosides in moderate to good yields and excellent stereoselectivity. The oxazolidinone ring can be opened with aqueous alkali hydroxide to liberate the amine functionality. This method has been successfully applied to the synthesis of the trisaccharide repeating unit of Streptococcus pneumoniae 19F polysaccharide.
Cesium carbonate-mediated stereoselective anomeric O-alkylation of a 2N,3O-oxazolidinone-protected d-mannosamine with sugar-derivedprimary or secondary alkyltriflates afforded the corresponding 2-amino-2-deoxy-beta-d-mannosides in moderate to good yields and excellent stereoselectivity.The oxazolidinone ring can be opened with aqueous alkali hydroxideto liberate the amine functionality. This method has been successfullyapplied to the synthesis of the trisaccharide repeating unit of Streptococcus pneumoniae 19F polysaccharide.
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