Rhodium-Catalyzed Enantioselective N-Allylation of Sulfoximines

The N-functionalization of free sulfoximines is an important approach to modifying their chemical and biological properties for downstream applications. Here, we report a rhodium-catalyzed N-allylation of free sulfoximines (=NH) with allenes under mild conditions. The redox-neutral and base-free process enables chemo-and enantioselective ?-hydroamination of allenes and gem-difluoroallenes. Synthetic applications of sulfoximine products obtained thereof have been demonstrated.

Automated summary

N-functionalization of free sulfoximines is a significant method for modifying their properties for various applications. This study presents a rhodium-catalyzed N-allylation of free sulfoximines (=NH) with allenes, enabling chemo- and enantioselective ?-hydroamination of allenes and gem-difluoroallenes. The synthesis of sulfoximine products using this method is also demonstrated.