Total Synthesis of Kopsone

A total synthesis of kopsone was achieved, featuring stereoselective preparation of an acyclic aldehyde having a protected hydroxylamine moiety via Ireland-Claisen rearrangement and intramolecular cycloaddition of an eight-membered cyclic nitrone to form the 2-azabicyclo[3.3.1]nonane skeleton.

Automated summary

A total synthesis of kopsone was achieved by stereoselective preparation of an acyclic aldehyde with a protected hydroxylamine moiety through Ireland-Claisen rearrangement and intramolecular cycloaddition of an eight-membered cyclic nitrone, forming the 2-azabicyclo[3.3.1]nonane skeleton.