4.8 Letter

Elemental Sulfur-Mediated Transformation of Carboxylic Acids to Acyl Fluorides by Electrophilic Fluorinating Reagent, Selectfluor

Journal

ORGANIC LETTERS
Volume 25, Issue 16, Pages 2810-2814

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00701

Keywords

-

Ask authors/readers for more resources

The synthesis of acyl fluorides from carboxylic acids is achieved using Selectfluor mediated by elemental sulfur. A wide range of acyl fluorides can be accessed while avoiding the formation of acid anhydrides. F-19 NMR spectra indicate that the reactive species in this deoxyfluorination reaction are the in situ generated S-8-fluoro-sulfonium cation A and neutral S-8-difluoride A'.
The elemental sulfur-mediated synthesis of acyl fluorides from carboxylic acids is achieved using Selectfluor. A broad range of acyl fluorides are accessible from carboxylic acids while avoiding the formation of acid anhydrides. F-19 NMR spectra suggest that S-8-fluoro-sulfonium cation A and neutral S-8-difluoride A ' generated in situ are the reactive species in this deoxyfluorination reaction.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available