Journal
ORGANIC LETTERS
Volume 25, Issue 19, Pages 3471-3475Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01050
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A novel persulfate-mediated oxidative glycosylation system using p-methoxyphenyl (PMP) glycosides as stable glycosyl donors is developed. Both K2S2O8 and Hf(OTf)4 are found to be crucial in activating the PMP group as a potential leaving group. This convenient protocol enables the synthesis of various biologically and synthetically important glycoconjugates, including glycosyl fluorides.
A novel persulfate-mediated oxidative glycosylation system using p-methoxyphenyl (PMP) glycosides as bench-stable glycosyl donors is developed. This study shows that both K2S2O8 as an oxidant and Hf(OTf)4 as a Lewis acid catalyst play important roles in the oxidative activation of the PMP group into a potential leaving group. This convenient glycosylation protocol proceeds under mild conditions and delivers a wide range of biologically and synthetically valuable glycoconjugates, including glycosyl fluorides.
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