Automated, Capsule-Based Suzuki-Miyaura Cross Couplings

The development of an automated process for Suzuki-Miyaura cross couplings is described, in which the complete reaction, workup, and product isolation are effected automatically with no user involvement, aside from loading of the starting materials and reaction capsule. This practical and simple method was successfully demonstrated to provide the desired biaryl products using a range of aryl bromides and boronic acids and is also effective for the late-stage functionalization of aryl halides in bioactive molecules.

Automated summary

The development of an automated process for Suzuki-Miyaura cross couplings is described, which involves automatic completion of the entire reaction, workup, and product isolation without any user involvement except for loading the starting materials and reaction capsule. This practical and simple method has been successfully demonstrated for the production of desired biaryl products using various aryl bromides and boronic acids, and it is also effective for late-stage functionalization of aryl halides in bioactive molecules.