4.8 Article

Automated, Capsule-Based Suzuki-Miyaura Cross Couplings

Journal

ORGANIC LETTERS
Volume -, Issue -, Pages -

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01057

Keywords

-

Ask authors/readers for more resources

The development of an automated process for Suzuki-Miyaura cross couplings is described, which involves automatic completion of the entire reaction, workup, and product isolation without any user involvement except for loading the starting materials and reaction capsule. This practical and simple method has been successfully demonstrated for the production of desired biaryl products using various aryl bromides and boronic acids, and it is also effective for late-stage functionalization of aryl halides in bioactive molecules.
The development of an automated process for Suzuki-Miyaura cross couplings is described, in which the complete reaction, workup, and product isolation are effected automatically with no user involvement, aside from loading of the starting materials and reaction capsule. This practical and simple method was successfully demonstrated to provide the desired biaryl products using a range of aryl bromides and boronic acids and is also effective for the late-stage functionalization of aryl halides in bioactive molecules.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available