Journal
ORGANIC LETTERS
Volume 25, Issue 17, Pages 3078-3082Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00885
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A metal-free and environmentally friendly approach to cyclohepta[b]indole and furo[3,4-b]carbazole frameworks via a three-component reaction from indoles, tertiary propargylic alcohols, and activated alkynes is described. The probable mechanism was proposed based on the isolation and characterization of a key intermediate. Gram-scale reaction and product derivatizations were performed to demonstrate the practicality of the developed methodology.
A robust metal-free and environmentally friendly approach to cyclohepta[b]indole and furo[3,4-b]carbazole frameworks via a three-component reaction from indoles, tertiary propargylic alcohols, and activated alkynes is described. A probable mechanism was proposed on the basis of the isolation and characterization of a key intermediate of the reaction. A gram-scale reaction and product derivatizations were also performed to demonstrate the practicality of the developed methodology.
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