Liraglutide versus semaglutide for weight reduction-a cost needed to treat analysis

Review Pharmacology & Pharmacy

High-Dose Once-Weekly Semaglutide: A New Option for Obesity Management

Courtney L. Bradley et al.

Summary: High-dose once-weekly semaglutide shows significant potential for weight reduction and favorable effects on cardiometabolic risk factors and glycemic indices. Despite common gastrointestinal adverse effects, the medication is generally well tolerated.

ANNALS OF PHARMACOTHERAPY (2022)

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Article Endocrinology & Metabolism

Liraglutide for Weight Management in the Real World: Significant Weight Loss Even if the Maximal Daily Dose Is Not Achieved

Liesbet Trenson et al.

Summary: This study demonstrates that patients prescribed liraglutide experienced significant weight loss over the initial 4-month period, regardless of the dose used. Additionally, the addition of metformin led to a small but significant additional weight loss.

OBESITY FACTS (2022)

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Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Endocrinology & Metabolism

Use of Liraglutide 3.0 mg for Weight Management in a Real-World Setting in Switzerland

Christiane Lundegaard Haase et al.

Summary: The study shows that liraglutide 3.0 mg, when combined with diet and exercise, leads to greater weight loss in obese patients compared to diet and exercise alone. In a real-world setting with low insurance coverage, most patients did not reach the recommended maintenance dose of 3.0 mg, but still experienced clinically significant weight loss when using liraglutide in conjunction with diet and exercise.

OBESITY FACTS (2021)

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Article Medicine, General & Internal