Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review

Context Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial. Objective The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats. Data Sources A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases. Data Extraction In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria. Data Analysis The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews. Conclusion High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.

Automated summary

High-fat diets have a negative effect on the bone structure of Wistar rats, and the strength of the effect depends on the diet composition and exposure time.