Determinant factors of bone health after long-term of Roux-en-Y gastric bypass surgery: A cross-sectional study

Objectives: The aim of this study was to evaluate bone health and the potential influencing factors of bone metabolism disorders in adults >5 y after Roux-en-Y gastric bypass (RYGB) surgery.Methods: In this cross-sectional study, patients who were >= 5 y post-RYGB were invited. Bone health consid-ered as bone mineral content (BMC) and bone mineral density (BMD) in this study was assessed by dual x-ray absorptiometry. We also assessed 25-hydroxy-vitamin D concentrations, individual ultraviolet B radia-tion levels, serum ionized calcium, alkaline phosphatase, parathyroid, anthropometric, and body composition.Results: The study evaluated 104 adults (90% women; 49.6 +/- 9.1 y old; postoperative period 8.7 +/- 2.2 y). Lumbar and femoral BMC and BMD were positively correlated to body mass index (BMI), appendicular lean mass (ALM), and negatively to %excess of weight loss (EWL). Femoral BMD was negatively correlated to age, and both femoral BMD and BMC were positively correlated to weekly exposed body part score. Sex, age, BMI, ALM, and weekly exposed body part score explained 35% and 54% of the total variance of femoral BMD and BMC, respectively.Conclusions: The present findings suggested that older age, lower BMI, higher %EWL, lower ALM, and lower weekly body part exposure score are important determinants in lowering BMD and BMC parameters in long-term post-bariatric surgery individuals, rather than serum 25-hydroxy-vitamin D and parathyroid.(c) 2022 Elsevier Inc. All rights reserved.

Automated summary

The aim of this study was to evaluate bone health and potential influencing factors of bone metabolism disorders in adults >5 years after Roux-en-Y gastric bypass (RYGB) surgery. Bone health was assessed using dual x-ray absorptiometry, and various factors were evaluated including vitamin D levels, UVB radiation levels, anthropometric measurements, and body composition. The study found that age, BMI, % excess of weight loss, appendicular lean mass, and weekly body part exposure score were important determinants in lowering femoral bone mineral density and bone mineral content in long-term post-bariatric surgery individuals, while serum vitamin D and parathyroid had less impact.