Journal
CEREBRAL CORTEX
Volume 26, Issue 4, Pages 1580-1589Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhu336
Keywords
astrocytes; insula; middle cerebral artery; paleocortex; piriform cortex
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Funding
- Japan Society for the Promotion of Science KAKENHI [22791802, 25293379, 26463192]
- Ministry of Education, Culture, Sports, Science and Technology
- Sato Fund, Nihon University School of Dentistry
- Grants-in-Aid for Scientific Research [26463192, 25293379, 22791802] Funding Source: KAKEN
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Cortical spreading depression (SD) is a self-propagating wave of depolarization accompanied by a substantial disturbance of the ionic distribution between the intra- and extracellular compartments. Glial cells, including astrocytes, play critical roles in maintenance of the extracellular environment, including ionic distribution. Therefore, SD propagation in the cerebral cortex may depend on the density of astrocytes. The present study aimed to examine the profile of SD propagation in the insular cortex (IC), which is located between the neocortex and paleocortex and is where the density of astrocytes gradually changes. The velocity of SD propagation in the neocortex, including the somatosensory, motor, and granular insular cortices (5.7 mm/min), was higher than that (2.8 mm/min) in the paleocortex (agranular insular and piriform cortices). Around thick vessels, including the middle cerebral artery, SD propagation was frequently delayed and sometimes disappeared. Immunohistological analysis of glial fibrillary acidic protein (GFAP) demonstrated the sparse distribution of astrocytes in the somatosensory cortex and the IC dorsal to the rhinal fissure, whereas the ventral IC showed a higher density of astrocytes. These results suggest that cortical cytoarchitectonic features, which possibly involve the distribution of astrocytes, are crucial for regulating the velocity of SD propagation in the cerebral cortex.
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