4.8 Review

Squamous-Cell Carcinoma of the Skin

Related references

Note: Only part of the references are listed.
Article Dermatology

Validation of four cutaneous squamous cell carcinoma staging systems using nationwide data

Zoe Claire Venables et al.

Summary: This study validated the performance of four cSCC staging systems in predicting metastasis, with the BWH system demonstrating the highest specificity and discriminative ability, while the AJCC8 system showed superior negative predictive value and homogeneity. Further improvement and refinement of current cSCC staging systems are needed.

BRITISH JOURNAL OF DERMATOLOGY (2022)

Article Dermatology

Recurrence Status, Perineural Invasion, and Hypothyroidism Are Associated With Lymph Node Metastasis in Cutaneous Squamous Cell Carcinoma: A Case-Control Study

Marissa Lobl et al.

Summary: Recurrent tumors, perineural invasion, lymphovascular invasion, size of 2 cm or greater, and hypothyroidism are important risk factors for lymph node metastasis in cutaneous SCC.

DERMATOLOGIC SURGERY (2022)

Article Dermatology

Cumulative incidence and disease-specific survival of metastatic cutaneous squamous cell carcinoma: A nationwide cancer registry study

Selin Tokez et al.

Summary: This study investigated the cumulative incidence and disease-specific survival of patients with metastatic cutaneous squamous cell carcinoma (mcSCC) in the Dutch population and assessed patient-based risk factors. The results showed that approximately 2% of cSCCs metastasize, with higher risk for men, increasing age, and immunocompromised patients. The 5-year disease-specific survival for patients with mcSCC was high.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Dermatology

Skin cancer: Primary, secondary, and tertiary prevention. Part II

Kristina D. Rojas et al.

Summary: Skin cancer is the most common diagnosed cancer globally, and understanding its natural history is crucial for developing effective prevention and control strategies. These strategies include health promotion, primary prevention, secondary prevention, and tertiary prevention.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Dermatology

Skin cancer: Primary, secondary, and tertiary prevention. Part I

Mariana Perez et al.

Summary: This article provides an overview of the natural history of skin cancer and its prevention strategies, focusing on melanoma and keratinocyte skin cancers. It covers the epidemiology, risk factors, and potential interventions for health promotion and primary prevention.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Review Dermatology

Analysis of mutations in cutaneous squamous cell carcinoma reveals novel genes and mutations associated with patient-specific characteristics and metastasis: a systematic review

Marissa B. Lobl et al.

Summary: This study conducted a comprehensive synthesis and analysis of SCC sequencing studies, identifying specific mutations correlated with demographic characteristics and differences in mutation patterns between localized and metastatic SCCs. These findings may have clinical applications.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2022)

Article Dermatology

Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-center

Emily S. Ruiz et al.

Summary: This study evaluated the impact of adjuvant radiation therapy on high T-stage cutaneous squamous cell carcinomas following clear margin surgery. Results showed that adjuvant radiation therapy significantly reduced the risk of local recurrence and locoregional recurrence.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Dermatology

Risk factors for metastatic cutaneous squamous cell carcinoma: Refinement and replication based on 2 nationwide nested case-control studies

Selin Tokez et al.

Summary: This study analyzed and replicated the risk factors for metastatic cutaneous squamous cell carcinoma (cSCC) using two different datasets. In addition to diameter and thickness, poor differentiation, invasion, male sex, perineural/lymphovascular invasion, and facial localization were identified as significant risk factors for metastatic cSCC.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Dermatology

Implications of Satellitosis or In-transit Metastasis in Cutaneous Squamous Cell Carcinoma A Prognostic Omission in Cancer Staging Systems

Timothy D. Smile et al.

Summary: This study found that satellitosis or in-transit metastasis (S-ITM) is associated with clinical outcomes in patients with cutaneous squamous cell carcinoma (CSCC), similar to node-positive patients. However, patients with S-ITM have an increased risk of recurrence and worse survival compared to patients with T3 and T4 disease. These findings suggest that S-ITM should be incorporated into clinical staging systems.

JAMA DERMATOLOGY (2022)

Article

Immune checkpoint inhibitors for solid organ transplant recipients: clinical updates

Shun Kawashima et al.

Korean Journal of Transplantation (2022)

Article Dermatology

Immune status does not independently influence cutaneous squamous cell carcinoma metastasis and death when stratified by tumor stage: A dual-center retrospective cohort analysis of primary N0 disease

Daniel M. O'Connor et al.

Summary: This study compared the outcomes of cutaneous squamous cell carcinoma in immunocompromised and immunocompetent patients. The results showed that while immunocompromised patients had more advanced T-stage tumors, adjusting for T-stage showed similar rates of metastasis and disease-specific death between the two groups.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Medicine, General & Internal

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

N. D. Gross et al.

Summary: This study evaluated the efficacy of cemiplimab as neoadjuvant therapy for resectable cutaneous squamous-cell carcinoma. The results showed a high percentage of patients achieved a pathological complete response with this treatment approach.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Dermatology

Skin cancer: Primary, secondary, and tertiary prevention. Part I

Mariana Perez et al.

Summary: Skin cancer is the most commonly diagnosed cancer worldwide, and prevention and control strategies can be categorized into health promotion, primary prevention, secondary prevention, and tertiary prevention. This review covers the epidemiology, risk factors, primordial prevention, and primary prevention of melanoma and keratinocyte skin cancers, while also discussing existing recommendations, challenges, opportunities, and future directions.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Dermatology

Skin cancer: Primary, secondary, and tertiary prevention. Part II

Kristina D. Rojas et al.

Summary: This article discusses the natural history of skin cancer and strategies for prevention and control, including health promotion, prevention, treatment, etc.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Article Medicine, Research & Experimental

High-Risk Cutaneous Squamous Cell Cancer of the Head and Neck: Risk Factors for Recurrence and Impact of Adjuvant Treatment

Samuel J. Trosman et al.

Summary: Despite adjuvant treatment, advanced HNcSCC has a high recurrence rate, with tumor size larger than 2 cm serving as a strong independent risk factor for recurrence. Among traditional HNcSCC risk factors, perineural invasion was most strongly associated with worse disease-free survival. The addition of chemotherapy did not show survival benefit for patients in this study.

LARYNGOSCOPE (2021)

Letter Dermatology

Efficacy and Cost Analysis for Acitretin for Basal and Squamous Cell Carcinoma Prophylaxis in Renal Transplant Recipients

Omar Badri et al.

Summary: Additional digital content is available in the text.

DERMATOLOGIC SURGERY (2021)

Article Dermatology

Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma

Ashley Wysong et al.

Summary: A gene expression profile (GEP) test was developed and validated to predict metastasis risk in high-risk cutaneous squamous cell carcinoma (cSCC) patients, improving risk-directed patient management.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Letter Dermatology

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in psoriasis and atopic dermatitis: A case-control study

Alberto Conde-Ferreiros et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Oncology

Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): an open-label, nonrandomized, multicenter, phase II trial

B. G. M. Hughes et al.

Summary: The study confirmed the robust anti-tumor activity of pembrolizumab in both locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma patients, showing durable efficacy without unexpected safety signals. Pembrolizumab may be a promising treatment option for these patients.

ANNALS OF ONCOLOGY (2021)

Article Oncology

PD-1 inhibition therapy for advanced cutaneous squamous cell carcinoma: a retrospective analysis from the University of Southern California

Gino K. In et al.

Summary: PD-1 inhibition therapy shows durable responses in patients with advanced or metastatic CSCC. Patients should be closely monitored for immune-related adverse events, especially those who are frail or immune-suppressed. Further research on potential biomarkers is needed to identify patients who will benefit the most from this therapeutic option.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

Review Oncology

Transplant rejections associated with immune checkpoint inhibitors: A pharmacovigilance study and systematic literature review

Lee S. Nguyen et al.

Summary: The study assessed the characteristics of rejection events in solid organ transplant recipients following the use of immune-checkpoint inhibitors (ICI) and identified drugs associated with rejection events. Primary kidney transplant rejection was linked to nivolumab, pembrolizumab, and ipilimumab, while liver transplant rejection was mainly over-reported with nivolumab.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

A critical analysis of the 8th edition TNM staging for head and neck cutaneous squamous cell carcinoma with lymph node metastases and comparison to N1S3 stage and ITEM risk score: A multicenter study

Ardalan Ebrahimi et al.

Summary: For head and neck cutaneous squamous cell carcinoma, the current AJCC N category and tumor node metastasis stage show poor patient distribution and predictive performance, while N1S3 and ITEM provide some predictive value but with limitations. Therefore, there is a need to develop a staging system specific to HNcSCC.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Article Oncology

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Renata Ferrarotto et al.

Summary: Neoadjuvant immunotherapy in locoregionally advanced, resectable cutaneous squamous cell carcinoma of the head and neck is safe and effective, inducing a high pathologic response rate. Pathologic responses were associated with an inflamed tumor microenvironment.

CLINICAL CANCER RESEARCH (2021)

Review Otorhinolaryngology

Adjuvant therapy for high-risk cutaneous squamous cell carcinoma: A 10-year review

Jason G. Newman et al.

Summary: The standard of care for high-risk cutaneous squamous cell carcinoma involves surgical excision with clear margins, but adjuvant therapy may be considered for certain high-risk factors. However, patient selection for adjuvant therapy remains unclear due to conflicting evidence and limited research. Prognostic tools and large-cohort clinical studies are needed to determine the most appropriate therapy and patient selection for high-risk cSCC.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

Review Dermatology

Consensus-Based Recommendations on the Prevention of Squamous Cell Carcinoma in Solid Organ Transplant Recipients A Delphi Consensus Statement

Paul R. Massey et al.

Summary: This study aimed to establish consensus-based medical management recommendations for the prevention of cutaneous squamous cell carcinoma in solid organ transplant recipients. Through a Delphi process involving dermatologists with experience treating SOTRs, consensus was reached on key recommendations for different stages of actinic damage and skin cancer. The panel was able to make recommendations for 5 out of 6 actinic damage and skin cancer index stages, highlighting the importance of tailored prevention strategies for high-risk patients.

JAMA DERMATOLOGY (2021)

Article Oncology

Cemiplimab for Locally Advanced and Metastatic Cutaneous Squamous-Cell Carcinomas: Real-Life Experience from the French CAREPI Study Group

Candice Hober et al.

Summary: The study found that cemiplimab was effective for patients with advanced cutaneous squamous-cell carcinomas regardless of immune status. Patients with good Eastern Cooperative Oncology Group performance status benefited more from cemiplimab, while the safety profile was acceptable. These findings support the use of cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas.

CANCERS (2021)

Article Otorhinolaryngology

Prognostic value of the 8th edition American Joint Commission Cancer nodal staging system for patients with head and neck cutaneous squamous cell carcinoma: A multi-institutional study

Peter P. Luk et al.

Summary: The study found that upgrading the classification of HNcSCC patients based on AJCC8 led to a high proportion of patients being reclassified, but the pN classification did not effectively predict survival outcomes, with the model performance being modest.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

Article Dermatology

Detection of subclinical disease with baseline and surveillance imaging in high-risk cutaneous squamous cell carcinomas

Jacqueline M. Maher et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Article Oncology

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment

Alexander J. Stratigos et al.

EUROPEAN JOURNAL OF CANCER (2020)

Letter Dermatology

Chronic nonmelanoma skin cancers and health-related impairment: A case-control study

Adam Sutton et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Review Dermatology

Nodal staging of high-risk cutaneous squamous cell carcinoma

Matthew Fox et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Article Medicine, General & Internal

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Dermatology

Incidence and mortality for cutaneous squamous cell carcinoma: comparison across three continents

A. Stang et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Review Dermatology

Review of Nonmelanoma Skin Cancer in African Americans, Hispanics, and Asians

Shauna Higgins et al.

DERMATOLOGIC SURGERY (2018)

Article Dermatology

Quantifying the Polygenic Contribution to Cutaneous Squamous Cell Carcinoma Risk

Joanne E. Sordillo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Dermatology

Guidelines of care for the management of cutaneous squamous cell carcinoma

Murad Alam et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Article Medicine, General & Internal

PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

M. R. Migden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Dermatology

The positive impact of radiologic imaging on high-stage cutaneous squamous cell carcinoma management

Emily Stamell Ruiz et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

Review Oncology

Systemic Therapy in Advanced Cutaneous Squamous Cell Carcinoma (CSCC) The Roswell Park Experience and a Review of the Literature

Anthony Jarkowski et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2016)

Review Oncology

Management of Skin Cancer in the High-Risk Patient

James W. Behan et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2016)

Article Medicine, General & Internal

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

Andrew C. Chen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Otorhinolaryngology

Distant metastases from cutaneous squamous cell carcinoma-analysis of AJCC stage IV

Markus Brunner et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2013)

Article Oncology

The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors

Nicholas D. L. S. Brougham et al.

JOURNAL OF SURGICAL ONCOLOGY (2012)

Article Medicine, General & Internal

Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis

Mackenzie R. Wehner et al.

BMJ-BRITISH MEDICAL JOURNAL (2012)

Article Dermatology

Prevalence of a History of Skin Cancer in 2007 Results of an Incidence-Based Model

Robert S. Stern

ARCHIVES OF DERMATOLOGY (2010)

Article Dentistry, Oral Surgery & Medicine

Cutaneous head and neck SCCs and risk of nodal metastasis - UK experience

Constantinos Mourouzis et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2009)

Article Dermatology

The Effect of Having an Affected Parent or Sibling on Invasive and In Situ Skin Cancer Risk in Sweden

Shehnaz K. Hussain et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Review Dermatology

Skin cancer in skin of color

Hugh M. Gloster et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2006)

Article Oncology

Mortality risk from squamous cell skin cancer

GL Clayman et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Article Biochemistry & Molecular Biology

The epidemiology of UV induced skin cancer

BK Armstrong et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2001)