4.4 Article

Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors

Related references

Note: Only part of the references are listed.
Article Neurosciences

Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation

Karolina Przepiorska et al.

Summary: Amorfrutin B is identified as a selective modulator of the PPAR gamma receptor with neuroprotective properties against hypoxic and ischemic damage in brain neurons. The delayed post-treatment with amorfrutin B prevents neuronal apoptosis by preserving mitochondrial function, inhibiting heterochromatin foci formation, and modulating the expression of specific genes and proteins. The protective mechanisms of amorfrutin B involve the inhibition of autophagy and the regulation of apoptosis-focused and autophagy-related miRNAs. Amorfrutin B shows promise as an anti-stroke therapeutic with a wide treatment window.

MOLECULAR NEUROBIOLOGY (2023)

Review Oncology

Management of genitourinary syndrome of menopause in breast cancer survivors: An update

Daniel Maria Lubian Lopez

Summary: Breast cancer survivors often experience discomfort symptoms caused by vulvovaginal atrophy after receiving adjuvant therapy. While lifestyle modifications and nonhormonal treatments can help alleviate symptoms in most cases, other treatment options may be considered when these methods are ineffective. However, there is a lack of evidence for the safety and effectiveness of these treatments, calling for further research in this area.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Resveratrol alleviates oxygen/glucose deprivation/reoxygenation-induced neuronal damage through induction of mitophagy

Ming Ye et al.

Summary: Resveratrol exerts neuroprotective effects on primary cortical neurons subjected to oxygen/glucose deprivation/reoxygenation (OGD/R) by modulating mitophagy, improving cell viability, suppressing apoptosis, alleviating loss of mitochondrial membrane potential and excessive oxidative stress. The protective effects are mediated, at least in part, by promoting mitophagy through the PTEN-induced kinase 1/Parkin pathway.

MOLECULAR MEDICINE REPORTS (2021)

Article Neurosciences

Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1

A. Wnuk et al.

Summary: The study demonstrates that PaPE-1 can inhibit hypoxia/ischemia-induced neuronal death in a delayed posttreatment, with a reduction in neurotoxicity and neurodegeneration. The neuroprotective effect is achieved through reducing ROS formation and restoring cellular metabolic activity.

NEUROTOXICITY RESEARCH (2021)

Article Biochemistry & Molecular Biology

Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia

Agnieszka Wnuk et al.

Summary: Amorfrutin B exhibits neuroprotective effects by modulating the PPARγ receptor, promoting mitochondrial integrity, and inhibiting ROS activity and DNA damage. The compound's actions on the PPARγ gene methylation and protein expression vary under hypoxic and ischemic conditions, suggesting complex regulatory mechanisms involved in its neuroprotective effects. Amorfrutin B also affects other epigenetic parameters, making it a promising therapeutic option for stroke treatment with a wide treatment window.

BIOMEDICINES (2021)

Review Medicine, General & Internal

Ospemifene in the Management of Vulvar and Vaginal Atrophy: Focus on the Assessment of Patient Acceptability and Ease of Use

Angelo Cagnacci et al.

PATIENT PREFERENCE AND ADHERENCE (2020)

Review Biochemistry & Molecular Biology

Exploring Perinatal Asphyxia by Metabolomics

Emanuela Locci et al.

METABOLITES (2020)

Review Medicine, Research & Experimental

Estrogen: The necessary evil for human health, and ways to tame it

Seema Patel et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Cell Biology

Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ERα and PPAR-γ

J. Rzemieniec et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

Article Medicine, General & Internal

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

Valery L. Feigin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, Research & Experimental

3-Daidzein sulfonate sodium inhibits neuronal apoptosis induced by cerebral ischemia-reperfusion

Ruizhen Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Review Biochemistry & Molecular Biology

Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System

Agnieszka Wnuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling

Malgorzata Kajta et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Article Neurosciences

The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity

A. Wnuk et al.

NEUROTOXICITY RESEARCH (2016)

Article Biochemistry & Molecular Biology

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

J. Rzemieniec et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Neurosciences

The neuroprotective actions of oestradiol and oestrogen receptors

Maria-Angeles Arevalo et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Article Toxicology

In vitro detection of cytotoxicity using FluoroJade-C

Qiang Gu et al.

TOXICOLOGY IN VITRO (2014)

Article Biochemistry & Molecular Biology

Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause

Mikko Unkila et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

Review Cell Biology

Defining the role of the Bcl-2 family proteins in Huntington's disease

J. Sassone et al.

CELL DEATH & DISEASE (2013)

Article Biochemistry & Molecular Biology

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Takashi Shichita et al.

NATURE MEDICINE (2012)

Review Endocrinology & Metabolism

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence

Denis Vivien et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)

Article Endocrinology & Metabolism

Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro

Jiabin Guo et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)

Article Biochemistry & Molecular Biology

Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro

Malgorzata Kajta et al.

NEUROCHEMISTRY INTERNATIONAL (2009)

Article Neurosciences

SOY PHYTOESTROGENS ARE NEUROPROTECTIVE AGAINST STROKE-LIKE INJURY IN VITRO

D. A. Schreihofer et al.

NEUROSCIENCE (2009)

Article Neurosciences

Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neuro degenerative disorders

Lucian Soane et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

Article Biochemistry & Molecular Biology

Bcl-2 changes conformation to inhibit Bax oligomerization

Paulina J. Dlugosz et al.

EMBO JOURNAL (2006)