4.7 Article

Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood

Related references

Note: Only part of the references are listed.
Article Neurosciences

Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex

Saige K. K. Power et al.

Summary: Cholinergic synapses in the prefrontal cortex play a critical role in attention, but undergo significant changes during adulthood. Studying these changes ex vivo, researchers discovered a decline in neurotransmission in middle adulthood, particularly in postsynaptic nicotinic receptor currents. However, other components of cholinergic synapses, such as acetylcholine autoinhibition and muscarinic receptor excitation, remained stable. By modulating nicotinic receptors and utilizing the second messenger pathways of muscarinic receptors, researchers were able to restore cholinergic signaling in older mice, demonstrating a potential pathway for cognitive enhancement.

NEUROPSYCHOPHARMACOLOGY (2023)

Article Neurosciences

Differential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio

Mathieu Lafourcade et al.

Summary: Synaptic NMDA receptors produce dendritic supralinearities, expanding computational capabilities of single neurons and circuits. Different inputs selectively target different dendritic compartments, exhibiting differential expression of supralinearity due to changes in receptor ratio. The coexistence of multiple modes of dendritic integration has important implications for synaptic plasticity and cortical computation.

NEURON (2022)

Review Neurosciences

The Guide to Dendritic Spikes of the Mammalian Cortex In Vitro and In Vivo

Matthew E. Larkum et al.

Summary: This article reviews the discovery of dendritic spikes in various neurons, compares their in vivo and in vitro characteristics, and discusses their presence in the human cortex. It focuses on neocortical and hippocampal neurons and presents an approach to identify and understand the broader role of dendritic spikes in single-cell computation.

NEUROSCIENCE (2022)

Article Multidisciplinary Sciences

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific

Martin Hruska et al.

Summary: This study reveals the impact of nanoscale organization of glutamate receptors on synaptic features, with receptors containing specific subunits forming specific subsynaptic regions, which is crucial for events such as cell death and synaptic plasticity.

NATURE COMMUNICATIONS (2022)

Article Neurosciences

Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron

Peng P. Gao et al.

Summary: In cortical pyramidal neurons, dendritic plateau potentials generated in response to spatially restricted glutamatergic inputs were recorded through voltage imaging, and a computer model was created to recreate experimental measures. The model predicted changes in neuronal state during plateau potentials, which were then tested in experiments. The plateau potentials triggered significant alterations in neuronal state, making the cell more susceptible to firing triggered by other afferent inputs.

JOURNAL OF NEUROPHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Consequences of NMDA receptor deficiency can be rescued in the adult brain

Catharine A. Mielnik et al.

Summary: NMDARs play a crucial role in brain development and connectivity, with dysfunction leading to various neurodevelopmental disorders. Restoring NMDAR function through gene editing in adulthood significantly improves cognitive functions, providing a new approach for the treatment of neurodevelopmental disorders.

MOLECULAR PSYCHIATRY (2021)

Article Multidisciplinary Sciences

An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization

Stephane Pages et al.

Summary: The organization and plasticity of cortical sensory maps depend on experience, particularly on the role of higher-order thalamocortically mediated plateau potentials in whisker map plasticity. Blocking the plateau potentials can restore the typical organization of sensory maps.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Neurosciences

Src and Fyn regulation of NMDA receptors in health and disease

Vishaal Rajani et al.

Summary: SFKs are crucial non-receptor tyrosine kinases in multiple signalling pathways, playing a key role in regulating NMDAR function and neuronal transduction pathways. Src and Fyn members of SFKs are essential for inducing plasticity at hippocampal synapses, while aberrant regulation of NMDARs by SFKs is implicated in diseases like schizophrenia and pain hypersensitivity. The targeting of SFK protein-protein interactions could be a potential therapeutic strategy for restoring glutamatergic dysregulation in CNS disease pathophysiology.

NEUROPHARMACOLOGY (2021)

Review Neurosciences

Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs

Tim A. Benke et al.

Summary: Recent discoveries have shown a significant genetic variation in NMDARs, with individuals carrying GRIN variants presenting with various neurological conditions. Understanding the functional consequences of these genetic variations could lead to precision therapeutics. Animal models with human variants may uncover shared mechanisms among different neurological conditions, requiring further research and clinical trials to validate and determine the effectiveness of treatment methods.

NEUROPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

Thomas Gonatopoulos-Pournatzis et al.

MOLECULAR CELL (2020)

Review Multidisciplinary Sciences

Linking glutamate receptor movements and synapse function

Laurent Groc et al.

SCIENCE (2020)

Article Neurosciences

Progressive neuroanatomical changes caused by Grin1 loss-of-function mutation

Katheron Intson et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Genetics & Heredity

GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function

Wenjuan Chen et al.

JOURNAL OF HUMAN GENETICS (2017)

Article Multidisciplinary Sciences

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Julie Jezequel et al.

NATURE COMMUNICATIONS (2017)

Article Neurosciences

Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex

Moritz Armbruster et al.

JOURNAL OF NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

Ai-Hui Tang et al.

NATURE (2016)

Article Mathematical & Computational Biology

Burst Firing Enhances Neural Output Correlation

Ho Ka Chan et al.

FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc

Charles T. Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Neurosciences

Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

Hao-wei Shen et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

Sensory-evoked LTP driven by dendritic plateau potentials in vivo

Frederic Gambino et al.

NATURE (2014)

Article Neurosciences

NMDA spikes enhance action potential generation during sensory input

Lucy M. Palmer et al.

NATURE NEUROSCIENCE (2014)

Article Neurosciences

Spiny neurons of amygdala, striatum, and cortex use dendr.tic plateau potentials to detect network UP states

Katerina D. Oikonomou et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Neurosciences

Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism

Lara J. Duffney et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

Thomas Papouin et al.

Article Neurosciences

Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex

Pascal Fossat et al.

CEREBRAL CORTEX (2012)

Review Biochemistry & Molecular Biology

Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia

Michael W. Salter et al.

FEBS JOURNAL (2012)

Article Neurosciences

Subcellular Synaptic Connectivity of Layer 2 Pyramidal Neurons in the Medial Prefrontal Cortex

Justin P. Little et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Neurosciences

Glutamate Spillover Promotes the Generation of NMDA Spikes

Jason R. Chalifoux et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Neurosciences

ORGANIZATION OF NMDA RECEPTORS AT EXTRASYNAPTIC LOCATIONS

R. S. Petralia et al.

NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex

Huaixing Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters

Samuel Andrew Hires et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Neurosciences

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

C. Geoffrey Lau et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Multidisciplinary Sciences

Reversal of neurological defects in a mouse model of Rett syndrome

Jacky Guy et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

NMDA receptor surface mobility depends on NR2A-2B subunits

Laurent Groc et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Neurosciences

SRC kinases: A hub for NMDA receptor regulation

MW Salter et al.

NATURE REVIEWS NEUROSCIENCE (2004)

Article Genetics & Heredity

Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation

P Tarpey et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2004)

Article Multidisciplinary Sciences

NMDA spikes in basal dendrites of cortical pyramidal neurons

J Schiller et al.

NATURE (2000)