Journal
NEUROPSYCHOLOGY REVIEW
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s11065-023-09578-3
Keywords
Neurocognitive disorders; Taste; Biomarkers; Systematic review; Meta-analysis
Categories
Ask authors/readers for more resources
This article systematically reviewed the studies on olfactory and gustatory dysfunction in NCDs and found that olfactory dysfunction has been extensively explored, while studies on gustatory dysfunction are limited. The results showed that gustatory dysfunction may exist in different types of NCDs and is associated with the severity of cognitive deficits.
Olfactory and gustatory dysfunction have been reported in mild and major neurocognitive disorders (NCDs), with variable results. While olfactory dysfunction has been consistently explored, reports on gustatory alterations are limited. We systematically reviewed case-control studies evaluating gustatory function in NCDs with various etiologies and different neuropathology. Eighteen studies were included in the systematic review, and eight were included in the meta-analysis. Most studies were on Alzheimer's disease (AD) and Parkinson's disease (PD). Pooled analyses showed worse global taste threshold and identification (sour in particular) scores in AD than controls and worse global, sweet, and sour scores in AD compared to mild cognitive impairment (MCI). PD with MCI showed worse global, sweet, salty, and sour scores than controls and cognitively unimpaired PD. Taste dysfunction was differentially associated with the severity of cognitive deficits. Gustatory dysfunction may represent a potential cross-disease chemosensory biomarker of NCD. Whether gustatory alterations may be a pre-clinical biomarker of NCD requires further studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available