Navigating Through the Recent Diagnostic Criteria for MOGAD Challenges and Practicalities

Article Clinical Neurology

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria

Brenda Banwell et al.

Summary: Serum antibodies against MOG can help diagnose MOGAD, which is distinct from multiple sclerosis and neuromyelitis optica. The presence of MOG-IgG is a core criterion for the diagnosis. MOGAD can present with various symptoms and can be either monophasic or relapsing, and diagnostic accuracy relies on MOG-IgG cell-based assays.

LANCET NEUROLOGY (2023)

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Article Clinical Neurology

Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System

Coral M. Stredny et al.

Summary: This study emphasizes the importance of pursuing non-invasive testing before performing a brain biopsy for suspected small vessel primary angiitis of the central nervous system.

ANNALS OF NEUROLOGY (2023)

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Article Clinical Neurology

Comparison of MRI Lesion Evolution in Different Central Nervous System Demyelinating Disorders

Elia Sechi et al.

Summary: MOGAD patients more frequently experience complete resolution of MRI T2 lesions compared to AQP4-IgG-NMOSD and MS. This finding has implications for diagnosis, disease activity monitoring, and clinical trial design, while also providing insights into the pathogenesis of CNS demyelinating diseases.

NEUROLOGY (2021)

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Article Clinical Neurology