Biomarkers: Role and Scope in Neurological Disorders

Neurological disorders pose a great threat to social health and are a major cause for mortality and morbidity. Effective drug development complemented with the improved drug therapy has made considerable progress towards easing symptoms associated with neurological illnesses, yet poor diagnosis and imprecise understanding of these disorders has led to imperfect treatment options. The scenario is complicated by the inability to extrapolate results of cell culture studies and transgenic models to clinical applications which has stagnated the process of improving drug therapy. In this context, the development of biomarkers has been viewed as beneficial to easing various pathological complications. A biomarker is measured and evaluated in order to gauge the physiological process or a pathological progression of a disease and such a marker can also indicate the clinical or pharmacological response to a therapeutic intervention. The development and identification of biomarkers for neurological disorders involves several issues including the complexity of the brain, unresolved discrepant data from experimental and clinical studies, poor clinical diagnostics, lack of functional endpoints, and high cost and complexity of techniques yet research in the area of biomarkers is highly desired. The present work describes existing biomarkers for various neurological disorders, provides support for the idea that biomarker development may ease our understanding underlying pathophysiology of these disorders and help to design and explore therapeutic targets for effective intervention.

Automated summary

Neurological disorders are a significant threat to social health and are responsible for high mortality and morbidity. Although drug development and therapy have improved, inadequate diagnosis and understanding of these disorders have hindered the effectiveness of treatment options. Biomarkers have been seen as a potential solution to the complexities of neurological disorders, providing insight into pathophysiology and guiding therapeutic interventions. However, challenges such as brain complexity, conflicting data, poor diagnostics, and high costs limit biomarker development. Research in this area is crucial for advancing our understanding and treatment of neurological disorders.