☆ 4.6 Article

Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis

NEURO-ONCOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells

Sarannya Edamana et al.

Summary: Aquaporin (AQP) water channels play a crucial role in the transport of water across cellular membranes and are associated with breast cancer. In vitro studies have shown that AQPs can influence the effectiveness of conventional anticancer chemotherapies. This study focused on AQP1, AQP3, and AQP5, which are often overexpressed in breast cancer, and evaluated their impact on the viability of breast cancer cell spheroids treated with different chemotherapies. The findings support the significant role of AQPs in the response to conventional chemotherapies and highlight the importance of understanding the individual proteins involved in resistance to chemotherapy for personalized medicine in breast cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023)

Add to Collection

Article Neurosciences

The absence of AQP4/TRPV4 complex substantially reduces acute cytotoxic edema following ischemic injury

Petra Sucha et al.

Summary: This study investigated the interaction between astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4 (TRPV4) channels and their impact on brain injury after stroke. The results showed that deleting AQP4 or TRPV4 channels alone worsened the ischemic brain injury, while deleting both channels resulted in a smaller initial brain lesion but similar tissue damage in the later phase as compared to controls. The study suggests that the interplay between AQP4 and TRPV4 channels plays a critical role in neuronal and non-neuronal swelling after ischemic injury.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

Add to Collection

Review Oncology

Aquaporins in Cancer Biology

Chul So Moon et al.

Summary: This article reviews recent research on the involvement of AQPs in tumor growth, angiogenesis, and metastasis, and explores their potential role in carcinogenesis. The study suggests that AQPs play a key role in tumor biology and may offer a unique opportunity for developing novel anti-tumor agents.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Review Oncology

Aquaporins: New players in breast cancer progression and treatment response

Verodia Charlestin et al.

Summary: Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport water and other small molecules and ions, playing important roles in various biological functions. This review discusses the roles of AQPs in breast cancer progression and metastasis, as well as their impact on the tumor microenvironment, highlighting their potential involvement in breast cancer. Additionally, AQPs have been identified as predictors of response to cancer therapy and targets for increasing treatment sensitivity. However, further research is needed to understand the molecular contributions of AQPs to therapeutic resistance in breast cancer.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Emerging therapeutic targets for cerebral edema

Ruchira M. Jha et al.

Summary: Cerebral edema is a significant factor in brain injury mortality and disability. Current treatments are limited, prompting the development of targeted therapies based on a growing understanding of the molecular mechanisms. Promising molecular targets, including ion and water channels and proteins/lipids involved in edema signaling pathways, are being investigated for their potential to reduce cerebral edema and improve clinical outcomes.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model

Nicole J. Sylvain et al.

Summary: Stroke is the second leading cause of death and the third leading cause of disability worldwide, with edema playing a major role in stroke-associated morbidity and mortality. Regulating water balance in the brain through targeting AQP4 channels may be a promising therapeutic approach for treating brain edema. The FDA-approved drug trifluoperazine (TFP) has shown efficacy in reducing cerebral edema in post-stroke mice by inhibiting AQP4 expression, without inducing deleterious changes in brain electrolytes or metabolic markers.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Philip Kitchen et al.

CELL (2020)

Add to Collection

Article Oncology

Impact of mouse strain and sex when modeling radiation necrosis

Andrew J. Boria et al.

RADIATION ONCOLOGY (2020)

Add to Collection

Article Oncology

Combination of Trastuzumab Emtansine and Stereotactic Radiosurgery Results in High Rates of Clinically Significant Radionecrosis and Dysregulation of Aquaporin-4

Priscilla K. Stumpf et al.

CLINICAL CANCER RESEARCH (2019)

Add to Collection

Article Multidisciplinary Sciences

Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking

Michael Nicosia et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Oncology

Radiation-induced astrocyte senescence is rescued by Δ133p53

Casmir Turnquist et al.

NEURO-ONCOLOGY (2019)

Add to Collection

Article Endocrinology & Metabolism

Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

Lorenz Hirt et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Add to Collection

Review Pharmacology & Pharmacy

The aquaporin-4 water channel as a potential drug target in neurological disorders

Alan S. Verkman et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2017)

Add to Collection

Review Endocrinology & Metabolism

Molecular pathophysiology of cerebral edema

Jesse A. Stokum et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

Add to Collection

Review Oncology

Updates in the management of brain metastases

Nils D. Arvold et al.

NEURO-ONCOLOGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Key roles of aquaporins in tumor biology

Marios C. Papadopoulos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Mechanisms of Astrocyte-Mediated Cerebral Edema

Jesse A. Stokum et al.

NEUROCHEMICAL RESEARCH (2015)

Add to Collection

Article Endocrinology & Metabolism

Posttraumatic reduction of edema with aquaporin-4 RNA interference improves acute and chronic functional recovery

Andrew M. Fukuda et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

Add to Collection

Review Neurosciences

Aquaporin water channels in the nervous system

Marios C. Papadopoulos et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Add to Collection

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Add to Collection

Article Multidisciplinary Sciences

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

Donald E. Kimbler et al.

PLOS ONE (2012)

Add to Collection

Article Clinical Neurology

Brain Water Content: a Misunderstood Measurement?

Richard F. Keep et al.

TRANSLATIONAL STROKE RESEARCH (2012)

Add to Collection

Article Clinical Neurology

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

Hironaka Igarashi et al.

NEUROLOGICAL SCIENCES (2011)

Add to Collection

Article Multidisciplinary Sciences

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

Alexander S. Thrane et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of Aquaporin 4 by antiepileptic drugs

Vincent J. Huber et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling

Baoxue Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Add to Collection

Review Clinical Neurology

Antiedema therapy in ischemic stroke

Juergen Bardutzky et al.

STROKE (2007)

Add to Collection

Review Clinical Neurology

Seizures and epilepsy in oncological practice: causes, course, mechanisms and treatment

Gagandeep Singh et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)

Add to Collection

Review Cell Biology

Cell senescence: Hypertrophic arrest beyond the restriction point

Mikhail V. Blagosklonny

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Add to Collection

Article Biology

Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain

AH Moore et al.

RADIATION RESEARCH (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons

CF Poulsen et al.

NEUROCHEMICAL RESEARCH (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of AQP4 expression in astrocytes by RNAi determines alterations in cell morphology, growth, and water transport and induces changes in ischemia related genes

GP Nicchia et al.

FASEB JOURNAL (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

GT Manley et al.

NATURE MEDICINE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.