Motor neuron-specific RhoA knockout delays degeneration and promotes regeneration of dendrites in spinal ventral horn after brachial plexus injury

Article Cell Biology

Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration

Wei Zhang et al.

Summary: Loading BMSC-derived extracellular vesicles into rGO-GelMA-PCL nerve conduits enhances peripheral nerve regeneration and recovery of neurological function.

NEURAL REGENERATION RESEARCH (2023)

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Article Nanoscience & Nanotechnology

Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix

Wen Xue et al.

Summary: Decellularized nerve hydrogels (dNHs) have shown promising effects on promoting Schwann cell proliferation and neurite outgrowth. The mechanics and components of the hydrogel contribute to its functionality, with laminin (LAM) and type V collagen (COLV) playing important roles. Additionally, by adding LAM and COLV to collagen hydrogels, gene expression of Schwann cells can be regulated, leading to improved spreading and neurite outgrowth. Furthermore, dNHs can be fabricated into paper-like, aligned nerve scaffolds for peripheral nerve injury treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Biochemistry & Molecular Biology

Peripheral Nerve Injury Treatments and Advances: One Health Perspective

Bruna Lopes et al.

Summary: Peripheral nerve injuries can result from various causes, with treatment options including surgery, pharmacological therapies, and cell-based therapies. However, achieving complete functional recovery remains difficult. Emphasizing the importance of new therapies, especially in severe lesions, is crucial to overcome limitations and achieve better outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury

Jingmin Liu et al.

Summary: Wallerian degeneration, the degeneration of distal axons and myelin after nerve injury, is crucial for nerve regeneration. This study found that microtubule dynamics are involved in this process, with microtubule stabilization promoting degeneration and dedifferentiation, while microtubule destabilization inhibiting these processes.

NEURAL REGENERATION RESEARCH (2022)

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Article Genetics & Heredity

Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1

Harjot Kaur Brar et al.

Summary: This study used the PVD neurons in C. elegans to investigate dendrite regeneration mechanisms, revealing a novel regulatory mechanism and quantifying regeneration patterns. Axonal injury did not affect dendrite regrowth, while the RAC GTPase CED-10 and its upstream GEF TIAM-1 were found to play crucial roles in dendrite regeneration.

PLOS GENETICS (2022)

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Article Immunology

Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice

Ke Zhong et al.

Summary: Brachial plexus root avulsion (BPRA) commonly occurs due to high-energy trauma, resulting in death of motoneurons and loss of motor and sensory function in the upper limb. The upregulation of aldose reductase (AR) in the spinal cord of BPRA mice is associated with disrupted autophagy, neuroinflammation, and motoneuron death. Furthermore, an AR inhibitor has shown neuroprotective effects against BPRA injury.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Multidisciplinary Sciences

A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster

Han-Hsuan Liu et al.

Summary: The study established a photo-switchable assay system for detecting dendrite degeneration and repair, and used the WldS protein as a test case to investigate the mechanisms underlying dendrite regeneration and repair.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Cell Biology

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

Qing Wang et al.

Summary: Ras homolog (Rho)-associated kinases (ROCKs) play a significant role in regulating the damage, survival, axon guidance, and regeneration of neurons. ROCKs are also involved in the development of neurodegenerative diseases and the biological effects of immune and glial cells. ROCKs inhibitors, like fasudil, have been found to attenuate the symptoms and progression of neurodegenerative diseases by inhibiting neuroinflammation, regulating immune imbalance, repairing the blood-brain barrier, and promoting nerve repair and myelin regeneration.

NEURAL REGENERATION RESEARCH (2022)

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Review Cell Biology

An electroencephalography-based human-machine interface combined with contralateral C7 transfer in the treatment of brachial plexus injury

Meng Zhang et al.

Summary: This review summarizes the progress of research in EEG-based human-machine interface combined with contralateral C7 transfer repair of brachial plexus nerve injury and discusses the impact of nerve and tendon transfer on neurological recovery.

NEURAL REGENERATION RESEARCH (2022)

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Review Neurosciences

Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease

Kotaro Furusawa et al.

Summary: Dendrites are essential for integrating neuronal information, with their development involving a precise interplay of growth, degeneration, and regeneration. Dysregulation of these processes is associated with pathology, injury, and aging.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Immunology

Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice

Jiawei Xu et al.

Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Cell Biology

5-HT6R null mutatrion induces synaptic and cognitive defects

Zehui Sun et al.

Summary: Research has shown that the absence of 5-HT6R affects cognitive function and anxiety levels in mice. 5-HT6R acting on primary cilia can impact neuronal morphology and transmission, leading to increased neuronal excitability.

AGING CELL (2021)

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Letter Biochemistry & Molecular Biology