Long-term effect of COVID-19 infection on kidney function among COVID-19 patients followed in post-COVID recovery clinics in British Columbia, Canada

Article Cell & Tissue Engineering

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jitske Jansen et al.

Summary: The study found that SARS-CoV-2 can directly infect kidney cells, leading to cell injury and fibrosis, causing kidney failure. Inhibitors can alleviate the infection.

CELL STEM CELL (2022)

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Article Multidisciplinary Sciences

Persistent COVID-19 symptoms in a community study of 606,434 people in England

Matthew Whitaker et al.

Summary: This study characterizes Long COVID using data from the REACT-2 community-based study in England, estimating the prevalence of persistent symptoms and identifying risk factors. It also finds evidence of symptom clustering.

NATURE COMMUNICATIONS (2022)

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Article Urology & Nephrology

The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study

Dennis G. Moledina et al.

Summary: The study revealed that COVID-19 patients have a higher incidence of acute kidney injury (AKI), and the independent association between COVID-19 and AKI was confirmed, possibly due to increased inflammatory markers and greater use of medications.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Urology & Nephrology

Proteinuria in COVID-19: prevalence, characterization and prognostic role

Justine Huart et al.

Summary: Proteinuria is common in patients with COVID-19, with elevated levels of urinary alpha(1)-microglobulin indicating tubular injury. These markers are associated with mortality in COVID-19 patients.

JOURNAL OF NEPHROLOGY (2021)

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Editorial Material Urology & Nephrology

The COVID-19 pandemic: consequences for nephrology

Annette Bruchfeld

Summary: The COVID-19 pandemic has had devastating consequences, with evidence showing that patients with kidney disease or at risk are disproportionately affected. Patients on dialysis or kidney transplant recipients are at higher risk of adverse outcomes, while patients with severe COVID-19 have an increased risk of acute kidney injury and potential long-term consequences for nephrological care.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Physiology

Proteinuria as a Biomarker for COVID-19 Severity

Hajar Ouahmi et al.

Summary: Renal involvement is common in moderate to severe SARS-CoV-2 infection, with significant proteinuria observed in 60% of patients. Proteinuria levels correlate with inflammatory markers and D-dimer concentrations, and higher levels are associated with increased risk of ICU admission. Additionally, proteinuria greater than 0.3 g/g is linked to longer hospital stays and higher risks of developing ARDS and nosocomial infections in COVID-19 patients.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Medicine, General & Internal

Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19

James Nugent et al.

Summary: In this retrospective cohort study, COVID-19-associated AKI was found to be associated with a greater rate of eGFR decrease after discharge compared with AKI in patients without COVID-19. This highlights the importance of monitoring kidney function and studying interventions to limit kidney disease after COVID-19-associated AKI.

JAMA NETWORK OPEN (2021)

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Article Nutrition & Dietetics

COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: A post-hoc analysis of a prospective cohort study

Luigi Di Filippo et al.

Summary: COVID-19 survivors may experience unintentional weight loss and malnutrition, with disease duration independently predicting weight loss. Nutritional evaluation, counseling, and treatment should be considered throughout the course of the disease and after clinical remission.

CLINICAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Weight trajectories and abdominal adiposity in COVID-19 survivors with overweight/obesity

Luigi Di Filippo et al.

Summary: COVID-19 survivors exhibit diverse changes in weight and abdominal adiposity during the three-month follow-up after discharge. Patients with overweight or obesity experience rapid weight fluctuations, which may worsen body composition in terms of abdominal adiposity.

INTERNATIONAL JOURNAL OF OBESITY (2021)

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Article Urology & Nephrology

Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19

Gaetano Alfano et al.

Summary: COVID-19 patients with acute kidney injury (AKI) had a incidence rate of 22.4%, with manifestations of proteinuria and microscopic hematuria. Risk factors for kidney injury included age, male sex, CKD, and higher non-renal SOFA score. Some patients required hemodialysis, and 33.3% of survivors did not recover kidney function after AKI.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2021)

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Article Urology & Nephrology

Kidney Outcomes in Long COVID

Benjamin Bowe et al.

Summary: The study showed that survivors of COVID-19 had an increased risk of kidney outcomes in the post-acute phase of the disease, indicating the importance of paying attention to kidney disease in long-term COVID-19 care.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Critical Care Medicine

Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: a cohort study

Nuttha Lumlertgul et al.

Summary: This retrospective study investigated acute kidney injury (AKI) in critically ill patients with COVID-19 in ICU, finding that AKI was highly prevalent in these patients with a portion progressing to severe stages requiring kidney replacement therapy. Steroid therapy may have a protective effect in reducing AKI progression.

ANNALS OF INTENSIVE CARE (2021)

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Article Urology & Nephrology