The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury

Article Biochemistry & Molecular Biology

Alpha-lipoic acid preconditioning plus ischemic postconditioning provides additional protection against myocardial reperfusion injury of diabetic rats: modulation of autophagy and mitochondrial function

Behnaz Mokhtari et al.

Summary: Pretreatment with LA in diabetic rats restored cardioprotection by IPostC via modulating autophagy and restoring mitochondrial function. This combined conditioning strategy may effectively reduce I/R damage in diabetic hearts.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Cell Biology

Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside

Hao Zhou et al.

Summary: Myocardial infarction is the irreversible death of cardiomyocytes due to prolonged lack of oxygen or fresh blood supply. Mitochondria, traditionally considered as energy powerhouses, are now recognized as signal regulators involved in various cellular functions. Mitochondrial quality surveillance is a network system that modifies mitochondrial structure and function through processes such as fission, fusion, biogenesis, bioenergetics, proteostasis, and degradation.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats

Aida Jafari-Azad et al.

Summary: The study shows that co-administration of nicotinamide mononucleotide and melatonin can effectively protect the aged heart from ischemia/reperfusion injury, reduce apoptosis, and activate the SIRT3/FOXO1 pathway.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Biochemistry & Molecular Biology

Modulation of autophagy as the target of mesenchymal stem cells-derived conditioned medium in rat model of myocardial ischemia/reperfusion injury

Behnaz Mokhtari et al.

Summary: This study demonstrated that hAM-MSCs-CM has cardioprotective effects against MI/R injury by modulating autophagy through the mTOR/ULK1 pathway, improving cardiac function and reducing fibrosis. These findings suggest that hAM-MSCs-CM may be a promising candidate for attenuating MI/R injury in the future, although further investigations are needed.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Biology

Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury

Wylly Ramses Garcia-Nino et al.

Summary: Ischemic preconditioning and postconditioning cardioprotective strategies target mitochondria to reduce I/R injury by activating protective signaling pathways and MQC processes, maintaining normal mitochondrial function and ensuring cardiomyocyte survival. MQC includes mitochondrial biogenesis, fission, fusion, mitophagy, and mitochondrial-controlled cell death. Modulation of MQC mechanisms and recognition of mitochondrial targets could offer a potential therapeutic approach for I/R-induced mitochondrial dysfunction.

LIFE-BASEL (2021)

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Review Cardiac & Cardiovascular Systems

Myocardial Ischemia-Reperfusion Injury: Therapeutics from a Mitochondria-Centric Perspective

Manli Zhou et al.

Summary: Coronary arterial disease is a common cardiovascular disease, and myocardial ischemia-reperfusion injury is a significant clinical issue after acute myocardial infarction. The mitochondrial quality control system plays a crucial role in maintaining cell homeostasis and survival.

CARDIOLOGY (2021)

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Review Cell Biology

The Role of Mitochondrial Quality Control in Cardiac Ischemia/Reperfusion Injury

Jia Huang et al.

Summary: Mitochondria play a crucial role in providing energy for myocardium and maintaining normal cell metabolism, while mitochondrial quality control is identified as a critical mechanism in ischemia/reperfusion injury.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Pharmacology & Pharmacy