Related references
Note: Only part of the references are listed.High-speed high-resolution data collection on a 200 keV cryo-TEM
Jared Peck et al.
IUCRJ (2022)
Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2
Lukas Gebauer et al.
BIOCHEMICAL PHARMACOLOGY (2022)
Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights
Nicholas J. Wright et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)
Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1
Marleen J. Meyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2022)
Structural basis of organic cation transporter-3 inhibition
Basavraj Khanppnavar et al.
NATURE COMMUNICATIONS (2022)
CHARMM-GUI high-throughput simulator for efficient evaluation of protein-ligand interactions with different force fields
Hugo Guterres et al.
PROTEIN SCIENCE (2022)
Structural basis for proton coupled cystine transport by cystinosin
Mark Löbel et al.
Nature Communications (2022)
Methotrexate recognition by the human reduced folate carrier SLC19A1
Nicholas J. Wright et al.
NATURE (2022)
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
Eric F. Pettersen et al.
PROTEIN SCIENCE (2021)
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates
Nan Wang et al.
CELL (2021)
CHARMM-GUI Supports Hydrogen Mass Repartitioning and Different Protonation States of Phosphates in Lipopolysaccharides
Ya Gao et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation
Ole Jensen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)
David Drew et al.
CHEMICAL REVIEWS (2021)
Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing
Hermann Koepsell
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)
Organic Cation Transporters in Health and Disease
Hermann Koepsell
PHARMACOLOGICAL REVIEWS (2020)
A drug-drug interaction study to evaluate the impact of peficitinib on OCT1-and MATE1-mediated transport of metformin in healthy volunteers
Mai Shibata et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2020)
Improving Protein-Ligand Docking Results with High-Throughput Molecular Dynamics Simulations
Hugo Guterres et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition
Zulfan Zazuli et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
Ali Punjani et al.
NATURE METHODS (2020)
Structures of human ENT1 in complex with adenosine reuptake inhibitors
Nicholas J. Wright et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Dorothee Liebschner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)
CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans
Jumin Lee et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2019)
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer
Thorsten Keller et al.
MOLECULAR PHARMACOLOGY (2019)
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization
Kazutaka Katoh et al.
BRIEFINGS IN BIOINFORMATICS (2019)
Molecular and cellular physiology of organic cation transporter 2
Stephen H. Wright
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)
MolProbity: More and better reference data for improved all-atom structure validation
Christopher J. Williams et al.
PROTEIN SCIENCE (2018)
Improvements to the APBS biomolecular solvation software suite
Elizabeth Jurrus et al.
PROTEIN SCIENCE (2018)
Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake
Valentin Gorboulev et al.
MOLECULAR PHARMACOLOGY (2018)
Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance
Maciej J. Zamek-Gliszczynski et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Jasenko Zivanov et al.
ELIFE (2018)
Consensus designs and thermal stability determinants of a human glutamate transporter
Erica Cirri et al.
ELIFE (2018)
Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency
Mladen V. Tzvetkov et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1)
Eugene C. Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
The Effect of Uremic Solutes on the Organic Cation Transporter 2
Kit Wun Kathy Cheung et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng et al.
NATURE METHODS (2017)
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Ali Punjani et al.
NATURE METHODS (2017)
OpenMM 7: Rapid development of high performance algorithms for molecular dynamics
Peter Eastman et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Gctf: Real-time CTF determination and correction
Kai Zhang
JOURNAL OF STRUCTURAL BIOLOGY (2016)
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
Esben M. Quistgaard et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules
Haim Ashkenazy et al.
NUCLEIC ACIDS RESEARCH (2016)
Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption
Ulrike M. Stamer et al.
PAIN (2016)
CTFFIND4: Fast and accurate defocus estimation from electron micrographs
Alexis Rohou et al.
JOURNAL OF STRUCTURAL BIOLOGY (2015)
A new class of accurate, mesh-free hydrodynamic simulation methods
Philip F. Hopkins
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY (2015)
Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers
Sung Kweon Cho et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2014)
CHARMM-GUI Membrane Builder Toward Realistic Biological Membrane Simulations
Emilia L. Wu et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2014)
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
April Goehring et al.
NATURE PROTOCOLS (2014)
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
Ligong Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Common Drugs Inhibit Human Organic Cation Transporter 1 (OCT1)-Mediated Neurotransmitter Uptake
Kelli H. Boxberger et al.
DRUG METABOLISM AND DISPOSITION (2014)
Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration
Mladen V. Tzvetkov et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity
Meijuan Tu et al.
TOXICOLOGY (2013)
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2
Jaclyn N. Harper et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
Bill R. Miller et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response
A. Bacq et al.
MOLECULAR PSYCHIATRY (2012)
Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
S. K. Cho et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Profiling of a Prescription Drug Library for Potential Renal Drug-Drug Interactions Mediated by the Organic Cation Transporter 2
Yasuto Kido et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions
G. Ahlin et al.
PHARMACOGENOMICS JOURNAL (2011)
Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin
Dong-Hyun Choi et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2010)
Jalview Version 2-a multiple sequence alignment editor and analysis workbench
Andrew M. Waterhouse et al.
BIOINFORMATICS (2009)
Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil
Takashi Sakugawa et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2009)
CHARMM: The Biomolecular Simulation Program
B. R. Brooks et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
I. S. Song et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Stereoselective first-pass metabolism of verapamil in the small intestine and liver in rats
Kazuhiko Hanada et al.
DRUG METABOLISM AND DISPOSITION (2008)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
Gustav Ahlin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices
Dmitry Gorbunov et al.
MOLECULAR PHARMACOLOGY (2008)
Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin
Min-Koo Choi et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2007)
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity
Alexander Sturm et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Yan Shu et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2
Ryan M. Pelis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2)
XH Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Automated electron microscope tomography using robust prediction of specimen movements
DN Mastronarde
JOURNAL OF STRUCTURAL BIOLOGY (2005)
Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease
C Popp et al.
MOLECULAR PHARMACOLOGY (2005)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: Implications for drug-drug interactions
S Neuhoff et al.
PHARMACEUTICAL RESEARCH (2003)
Share Paper
