Chimeric receptors broaden the therapeutic landscape for autoimmune disease

Article Biotechnology & Applied Microbiology

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Sangwook Oh et al.

Summary: Engineered T cells expressing MuSK-CAART effectively target B cells expressing anti-MuSK autoantibodies, reducing muscle weakness caused by autoimmune disease.

NATURE BIOTECHNOLOGY (2023)

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News Item Dermatology

CD19 CAR T cell therapy effective for systemic lupus erythematosus

J. Gelfand

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2023)

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Letter Medicine, General & Internal

CD19-targeted CAR T cells in refractory antisynthetase syndrome

Fabian Mueller et al.

LANCET (2023)

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Article Immunology

CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis

Karen B. Whittington et al.

Summary: By engineering an HLA-DR1 chimeric Ag receptor (CAR), researchers have produced CD8(+) CAR T cells that specifically target CD4(+) T cells in an Ag-specific manner. These CAR T cells have shown the ability to inhibit the development of autoimmune arthritis in a mouse model, suggesting their potential as a highly specific therapeutic approach for autoimmune disease.

JOURNAL OF IMMUNOLOGY (2022)

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Article Immunology

Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity

Jaeu Yi et al.

Science Immunology (2022)

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Article Biochemistry & Molecular Biology

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus

Andreas Mackensen et al.

Summary: A study of five patients with refractory systemic lupus erythematosus treated with anti-CD19 CAR T cell therapy showed remission of SLE disease in all patients after 3 months, and long-term drug-free remission was maintained during follow-up.

NATURE MEDICINE (2022)

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Letter Cell & Tissue Engineering