Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 24, Issue 8, Pages 517-518Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41580-023-00594-y
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In this Comment, the authors highlight the non-apoptotic roles of BCL-2 proteins in regulating cellular senescence and caution against the use of BCL-2 inhibitors as senolytics. While BCL-2 and related proteins are known for their role in apoptosis regulation, recent findings suggest their involvement in cellular senescence through non-apoptotic mechanisms.
In this Comment, the authors draw attention to non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence and voice the need for caution in using BCL-2 inhibitors as senolytics. BCL-2 and related proteins are major regulators of apoptosis that have emerged as promising targets for the elimination senescent cells (or 'senolysis') to improve age-related diseases and promote healthy ageing. However, seminal observations and recent findings shed light on non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence.
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