Carbon nanotubes activate inflammatory signalling through binding to Siglec-14

Discovery of a novel axis through which multi-walled carbon nanotubes (MWCNTs) elicit toxicity in human macrophages, involving the propagation of inflammatory signalling via the Siglec-14-DAP12-Syk pathway, and how it may be controlled pharmacologically.

Automated summary

The study discovers a new pathway, Siglec-14-DAP12-Syk, through which multi-walled carbon nanotubes induce inflammation and toxicity in human macrophages. The findings also suggest potential pharmacological strategies for controlling this response.