☆ 4.7 Article

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

NATURE IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Immunology

Germinal Centers

Gabriel D. Victora et al.

Summary: This paper reviews recent developments in the field of germinal center (GC) biology, specifically in GCs induced by infection or immunization. It summarizes the phenotype and function of different cell types in the GC, focusing on GC B cells. It also examines the cellular and molecular basis of affinity-dependent selection within the GC and the export of memory and plasma cells. Additionally, it provides an overview of the emerging field of GC clonal dynamics and its impact on the diversity of antibodies secreted into serum.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Germinal centre-driven maturation of B cell response to mRNA vaccination

Wooseob Kim et al.

Summary: SARS-CoV-2 mRNA vaccination induces a persistent germinal center reaction in humans, resulting in affinity-matured long-term antibody responses that potently neutralize the virus.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

Sarah Adamo et al.

Summary: Researchers used spectral flow cytometry combined with cellular indexing of transcriptomes and T cell receptor sequencing to longitudinally characterize individual SARS-CoV-2-specific CD8(+) T cells from patients with COVID-19, identifying a distinct signature marking long-lived memory CD8(+) T cells. The study found that SARS-CoV-2-specific memory CD8(+) T cells persisting 1 year after acute infection express specific markers and exhibit characteristics resembling effector memory T cells, and that certain transcriptional signatures and signaling pathways are associated with the fate of individual clones of these cells.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Carlo Cervia et al.

Summary: By studying the immunoglobulin signature of COVID-19 patients and combining it with factors such as age, history of asthma, and symptoms during the primary infection, the risk of post-acute COVID-19 syndrome (PACS) can be predicted independently of the timepoint of blood sampling.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles

Hyon-Xhi Tan et al.

Summary: Recent studies have found that memory B cells can reside in inflamed tissues for a long time. This study characterized tissue-resident memory B cells in the lungs of mice after influenza infection and discovered that the mechanisms underlying their localization may be evolutionarily conserved.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

Lauren B. Rodda et al.

Summary: Research found that individuals previously infected with SARS-CoV-2 generate more specific memory B cells, variant-neutralizing antibodies, and a distinct population of memory CD4(+) T cells compared to those who were previously naive. Additional vaccination does not replicate the unique CD4(+) T cell cytokine profile observed in previously infected individuals.

CELL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Rishi R. Goel et al.

Summary: This study examined the antibody and memory B cell responses after 2-dose mRNA vaccination against SARS-CoV-2 for a period of 9-10 months, as well as 3 months after a third dose. The results showed that antibody decay stabilized between 6 and 9 months, and the quality of antibodies continued to improve for at least 9 months after the second dose. The study also found that Spike and RBD-specific memory B cells remained durable over time, and a significant portion of RBD-specific memory B cells could bind to multiple variants. Omicron-binding memory B cells were efficiently activated by a third dose of the wild-type vaccine, leading to an increase in neutralizing antibody titers.

CELL (2022)

Add to Collection

Review Immunology

Instructing durable humoral immunity for COVID-19 and other vaccinable diseases

Deepta Bhattacharya

Summary: Many aspects of SARS-CoV-2 have followed the principles established by viral immunology research, leading to effective COVID-19 vaccines. However, there are areas where our knowledge is lacking, such as the duration of immunity after infection or vaccination and the effectiveness of booster shots. In this article, the author discusses lessons from other infections and vaccines that can help improve durable immunity. They highlight the importance of innate sensors, antigen delivery kinetics, B cell receptors, and memory B cell subsets in antibody production and immune response. Understanding these factors better can provide a rational framework for developing vaccines that offer long-lasting immunity.

IMMUNITY (2022)

Add to Collection

Article Biochemical Research Methods

Phylogenetic analysis of migration, differentiation, and class switching in B cells

Kenneth B. Hoehn et al.

Summary: This study developed parsimony-based summary statistics to characterize migration, differentiation, and isotype switching along B cell phylogenetic trees, demonstrating their effectiveness through simulations and application in HIV and allergy patient datasets.

PLOS COMPUTATIONAL BIOLOGY (2022)

Add to Collection

Article Immunology

Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

Christine S. Hopp et al.

Summary: During acute infection, Plasmodium-specific atypical B cells (atBCs) exhibit similar intracellular signaling cascades to activated B cells (actBCs) and have distinct transcriptional characteristics. These atBCs may play a role in humoral immune responses.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Review Immunology

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi et al.

Summary: This review summarizes key observations of humoral immune responses in people with COVID-19, discusses key features of infection- and vaccine-induced neutralizing antibodies, and explores vaccine designs for inducing broadly protective antibodies against different variants of the SARS-CoV-2 virus.

NATURE IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells

Rui Yang et al.

Summary: This study describes a patient with inherited T-bet deficiency who showed largely normal humoral immunity but exhibited skewed class switching and a specific subset of B cell development. T-bet was found to play an essential role in the development of a distinct subset of human B cells characterized by reduced expression of CD21 and high expression of CD19, CD20, CD11c, FCRL5, and T-bet.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Human T-bet governs the generation of a distinct subset of CD11c(high)CD21(low) B cells

Rui Yang et al.

Summary: In this study, a patient with inherited T-bet deficiency was described, who had largely normal humoral immunity but abnormal class switching and development of a specific subset of B cells. T-bet plays an important role in the differentiation of human CD11c(hi)CD21(lo) B cells.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Aurelien Sokal et al.

Summary: Memory B cells play a crucial role in host defense against SARS-CoV-2, with distinct B cell clone responses to the virus contributing to long-lasting immune protection. The study also highlights the significance of somatic mutations in the variable region genes of memory B cells over time, indicating continued maturation and long-term immune memory post-infection.

CELL (2021)

Add to Collection

Article Allergy

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

Carlo Cervia et al.

Summary: The study found that severe COVID-19 patients experienced a significant increase in SARS-CoV-2 antibody titers after symptom onset, especially with high IgA titers, while mild cases may exhibit transient production of SARS-CoV-2-specific antibodies. Interestingly, some healthcare workers with negative serum antibody titers showed SARS-CoV-2-specific IgA in mucosal fluids with virus-neutralizing capacity in some cases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

Raphael A. Reyes et al.

Summary: The research found subtle differences in the memory B cell response after non-severe and severe COVID-19, indicating that the memory B cell response elicited during non-severe COVID-19 may be of higher quality than the response after severe disease.

PLOS ONE (2021)

Add to Collection

Article Cell Biology

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Henry J. Sutton et al.

Summary: Using single-cell RNA sequencing, researchers explored the diversity of human B cells in healthy individuals and those exposed to malaria, identifying two distinct lineages with atypical B cells being part of the alternative lineage. Upon malaria vaccination, the alternative lineage cells respond to initial immunization and booster doses, but develop an atypical phenotype with repeated boosts, indicating that atypical cells are a normal component of healthy immune responses.

CELL REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Irene A. Abela et al.

Summary: The study found that higher levels of HCoV antibodies are associated with SARS-CoV-2 negativity, while in SARS-CoV-2 positive patients, higher HCoV activity is associated with elevated SARS-CoV-2 responses. Patients with high HCoV reactivity are less likely to require hospitalization.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Mrunal Sakharkar et al.

Summary: The study on the kinetics and evolution of the human B cell response to SARS-CoV-2 infection revealed that serum neutralizing antibody responses declined rapidly, while spike-specific IgG(+) memory B cells remained stable or increased over time. The research also showed evidence for prolonged antibody affinity maturation and the impact of mutations in the S protein on the neutralizing antibody response.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Cell Biology

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines

Kathryn A. Pape et al.

Summary: Infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs compared to vaccine-induced primary MBCs. These results suggest that infection-induced primary MBCs have undergone more affinity maturation and produce more robust secondary responses.

CELL REPORTS (2021)

Add to Collection

Article Immunology

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets

Haley L. Dugan et al.

Summary: Analyzing the evolution of memory B cells (MBCs) against SARS-CoV-2 is crucial for understanding antibody recall upon secondary exposure. Single-cell sequencing was used to profile SARS-CoV-2-reactive B cells in COVID-19 patients, revealing enrichment of SARS-CoV-2 spike-specific cells in the memory compartment and highly mutated variable genes in endemic HCoV-reactive antibody-secreting cells. Additionally, MBCs exhibited pronounced maturation to NP and ORF8 over time.

IMMUNITY (2021)

Add to Collection

Article Medicine, Research & Experimental

Durable SARS-CoV-2 B cell immunity after mild or severe disease

Clinton O. Ogega et al.

Summary: Research has shown that individuals infected with SARS-CoV-2 develop S-RBD-specific, class-switched rMBCs, regardless of disease severity. This provides evidence for sustained B cell-mediated immunity against the virus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Immunology

The expansion of human T-bethighCD21low B cells is T cell dependent

Baerbel Keller et al.

Summary: The accumulation of CD21(low) B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders. The transcription factor T-bet plays a prominent role in the regulation of T-bet(high)CD21(low) B cells, and essential signals such as BCR and IFN gamma R are crucial for the differentiation and expansion of these cells. Identification of important pathways provides potential targets for auto-reactive T-bet(high)CD21(low) B cells in autoimmune conditions.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Immunology

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Maya M. L. Poon et al.

Summary: Research has shown that SARS-CoV-2-specific immune memory persists in organs for up to 6 months post-infection, with lungs and lymph nodes being the most prevalent sites, indicating coordinated local tissue immunity for protection against future infections.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.

CELL (2021)

Add to Collection

Article Multidisciplinary Sciences

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

Zijun Wang et al.

Summary: Despite challenges posed by COVID-19 variants, convalescent individuals receiving mRNA vaccines exhibit robust and long-lasting immune responses against circulating SARS-CoV-2 variants, providing hope for effective control of the pandemic.

NATURE (2021)

Add to Collection

Article Immunology

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

Julia Niessl et al.

Summary: The study found that in individuals who had not been exposed to SARS-CoV-2, the frequencies of SARS-CoV-2-specific memory CD4(+) T cells were similar in tonsils and peripheral blood, but functional SARS-CoV-2-specific memory CD8(+) T cells were mostly found in tonsils. This suggests that preexisting tissue-resident memory CD8(+) T cells in unexposed individuals could potentially mount rapid immune responses against SARS-CoV-2.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Prasida Holla et al.

Summary: The study identified a distinct population of B cells called atypical B cells (ABCs) in chronic infectious diseases, such as malaria, HIV, and autoimmune diseases. These ABCs may represent a separate B cell lineage with common inducers, diversifying and acquiring disease-specific characteristics and functions. In malaria, ABC subsets were identified based on isotype expression, showing differences in expansion and B cell receptor repertoire characteristics in African children.

SCIENCE ADVANCES (2021)

Add to Collection

Article Immunology

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

John L. Johnson et al.

IMMUNITY (2020)

Add to Collection

Article Hematology

Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype

Nadine M. Weisel et al.

BLOOD (2020)

Add to Collection

Article Multidisciplinary Sciences

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Davide F. Robbiani et al.

NATURE (2020)

Add to Collection

Article Immunology

Naive- and Memory-like CD21low B Cell Subsets Share Core Phenotypic and Signaling Characteristics in Systemic Autoimmune Disorders

Mirjam Freudenhammer et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Immunology

The Antigen Presenting Potential of CD21low B Cells

Marlene E. Reincke et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Immunology

Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity

Rebecca A. Elsner et al.

IMMUNITY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates

Charlotte Viant et al.

CELL (2020)

Add to Collection

Article Immunology

Tissue-Resident T Cells and Other Resident Leukocytes

David Masopust et al.

Annual Review of Immunology (2019)

Add to Collection

Article Multidisciplinary Sciences

The single-cell transcriptional landscape of mammalian organogenesis

Junyue Cao et al.

NATURE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

B Cell Responses: Cell Interaction Dynamics and Decisions

Jason G. Cyster et al.

CELL (2019)

Add to Collection

Article Biology

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

Esther Zumaquero et al.

ELIFE (2019)

Add to Collection

Article Immunology

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

Sarah F. Andrews et al.

IMMUNITY (2019)

Add to Collection

Article Cell Biology

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

James W. Austin et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity

Ian Setliff et al.

CELL (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

Laleh Haghverdi et al.

NATURE BIOTECHNOLOGY (2018)

Add to Collection

Article Cell Biology

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Add to Collection

Article Medicine, Research & Experimental

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

Alice R. Burton et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Add to Collection

Article Immunology

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Scott A. Jenks et al.

IMMUNITY (2018)

Add to Collection

Article Gastroenterology & Hepatology

Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet plus tissue-like memory B cells

L. -Y. Chang et al.

JOURNAL OF VIRAL HEPATITIS (2017)

Add to Collection

Article Immunology

Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation

Denise Lau et al.

SCIENCE IMMUNOLOGY (2017)

Add to Collection

Article Medicine, Research & Experimental

T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response

James J. Knox et al.

JCI INSIGHT (2017)

Add to Collection

Review Immunology

Age-associated B cells: key mediators of both protective and autoreactive humoral responses

Martin S. Naradikian et al.

IMMUNOLOGICAL REVIEWS (2016)

Add to Collection

Article Biochemical Research Methods

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Zuguang Gu et al.

BIOINFORMATICS (2016)

Add to Collection

Article Immunology

Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

Burton E. Barnett et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Immunology

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

Ali H. Ellebedy et al.

NATURE IMMUNOLOGY (2016)

Add to Collection

Article Biochemical Research Methods

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data

Namita T. Gupta et al.

BIOINFORMATICS (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

Jacob H. Levine et al.

CELL (2015)

Add to Collection

Article Immunology

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

Claudia X. Dominguez et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Add to Collection

Review Immunology

Memory B cells

Tomohiro Kurosaki et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Add to Collection

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Add to Collection

Article Immunology

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

Whitney E. Purtha et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Add to Collection

Review Immunology

From Vaccines to Memory and Back

Federica Sallusto et al.

IMMUNITY (2010)

Add to Collection

Article Immunology

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

Greta E. Weiss et al.

JOURNAL OF IMMUNOLOGY (2009)

Add to Collection

Article Multidisciplinary Sciences

Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment

Christopher L. Haga et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.