Mediterranean mechanisms of longevity

Article Cell Biology

Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids

Katharina Papsdorf et al.

Summary: A study found that dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. The mechanisms by which MUFAs extend lifespan involve an organelle network involving lipid droplets and peroxisomes. MUFAs increase the number of lipid droplets and peroxisomes, and this regulation of organelle abundance is critical for MUFA-induced longevity.

NATURE CELL BIOLOGY (2023)

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Article Multidisciplinary Sciences

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Yoshikazu Johmura et al.

Summary: Research has shown that senescent cells rely on glutaminolysis for survival, and inhibiting this process can induce senolysis. Lysosomal membrane damage lowers intracellular pH in senescent cells, inducing KGA expression, leading to glutaminolysis, and ultimately producing ammonia to neutralize low pH and improve cell survival.

SCIENCE (2021)

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Article Multidisciplinary Sciences