Journal
NATURE CELL BIOLOGY
Volume 25, Issue 3, Pages 379-380Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-022-01084-7
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A recent study reveals that the deactivation of the immune adaptor protein STING is mediated by the encapsulation of STING-carrying vesicles by lysosomal compartments through microautophagy.
Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments - through the process of microautophagy - mediates the termination of STING signalling.
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