LDLs take a shortcut to mitochondria

Receptor-mediated endocytosis delivers low-density lipoproteins (LDLs) to late endosomes, from where cholesterol is trafficked to mitochondria. Zhou et al. report that LDL-containing endosomes fuse with mitochondria, supplying cholesterol for steroid biosynthesis and enabling mitochondrial degradation of the LDL receptor.

Automated summary

Receptor-mediated endocytosis transports LDLs to late endosomes, where cholesterol is delivered to mitochondria. Zhou et al. discovered that LDL-containing endosomes fuse with mitochondria, providing cholesterol for steroid biosynthesis and enabling mitochondrial degradation of the LDL receptor.