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Extrachromosomal DNA appears before cancer forms

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NATURE
Volume -, Issue -, Pages -

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NATURE PORTFOLIO
DOI: 10.1038/d41586-023-00982-6

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The discovery of extrachromosomal DNA in non-cancerous tissue challenges the previous belief that it is exclusive to cancer cells, suggesting its potential early involvement in malignant transformation.
A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation.

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