Related references
Note: Only part of the references are listed.
Article
Multidisciplinary Sciences
Alexander Hooftman et al.
Summary: Metabolic rewiring through an inflammatory aspartate-argininosuccinate shunt induces fumarate-mediated protein succination and inflammatory effects in macrophages. Inhibition of fumarate hydratase (FH) increases fumarate levels, suppresses mitochondrial respiration, and enhances interferon responses. FH inhibition may play a pathogenic role in systemic lupus erythematosus. These findings highlight the importance of FH in regulating macrophage functions and cytokine responses.
Article
Multidisciplinary Sciences
Vincent Zecchini et al.
Summary: The loss of FH in the kidney leads to early changes in mitochondrial morphology and the release of mtDNA into the cytosol, which activates the cGAS-STING-TBK1 pathway and induces an inflammatory response. This phenomenon is mediated by mitochondrial-derived vesicles and depends on SNX9. These findings demonstrate that increased levels of intracellular fumarate trigger a remodelling of the mitochondrial network and the generation of mitochondrial-derived vesicles, resulting in the release of mtDNA in the cytosol and the activation of the innate immune response.
Review
Immunology
Saverio Marchi et al.
Summary: This article discusses the molecular mechanisms by which mitochondrial dysfunction leads to inflammatory reactions, the cellular pathways that regulate them, and the pathological consequences of dysregulated inflammatory responses elicited by mitochondrial damage-associated molecular patterns (DAMPs).
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Cell Biology
Baiyu He et al.
Summary: This study reveals the crucial role of cristae architecture in preventing mtDNA release and inflammation. The disruption of cristae organizers leads to mtDNA release and the immune response. These findings provide mechanistic insights into the link between mitochondrial cristae disorganization and inflammation, which are emerging hallmarks of aging and age-related degenerative diseases.
Article
Oncology
Pei Dong et al.
Summary: This study analyzed the genomic characteristics and microenvironment of FHRCC and the cause of heterogeneous response to immune checkpoint inhibitor (ICI)-based treatment. The results showed that FHRCC had frequent immune infiltration and ICI treatment was associated with improved overall response rate and disease control rate. However, ICI treatment could not reverse the exhaustion of CD8+ T cells in patients with progressive disease, highlighting the need for additional therapeutic strategies.
CLINICAL CANCER RESEARCH
(2022)
Article
Ram Prosad Chakrabarty et al.
Article
Multidisciplinary Sciences
Marco Tigano et al.
Summary: The study reveals that mtDSBs activate a type-I interferon response, leading to the phosphorylation of STAT1 and activation of interferon-stimulated genes. After breaks in mtDNA, herniation mediated by BAX and BAK releases mitochondrial RNA into the cytoplasm and triggers a RIG-I-MAVS-dependent immune response.
Article
Rheumatology
Stavros Giaglis et al.
Summary: The study found that circulating mtDNA levels are significantly increased in SLE patients compared to healthy controls, and are associated with SLE disease activity. mtDNA levels can sensitively distinguish SLE patients from healthy individuals and serve as an independent marker of SLE activity.
Article
Multidisciplinary Sciences
Kiran Todkar et al.
Summary: Mitochondrial content in extracellular vesicles (EVs) can exacerbate inflammation, while its role in non-inflammatory conditions remains unclear. The research demonstrates that mitochondria-derived vesicles target material to EVs, while Parkinson's disease-related protein Parkin directs damaged mitochondrial content to lysosomes, shedding light on mitochondria-driven immune responses.
NATURE COMMUNICATIONS
(2021)
Review
Urology & Nephrology
Cissy Yong et al.
NATURE REVIEWS NEPHROLOGY
(2020)
Article
Multidisciplinary Sciences
A. Phillip West et al.
Article
Multidisciplinary Sciences
Liang Zheng et al.
NATURE COMMUNICATIONS
(2015)
Review
Biochemistry & Molecular Biology
Ayumu Sugiura et al.