A new biphenyl from the stem bark of Garcinia macrantha ACSm

In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable alpha-glucosidase inhibition of 58.20 +/- 0.37% in sucrose substrate and 39.86 +/- 2.07% in maltose substrate at 100 mu g/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The alpha-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.

Automated summary

In our study on antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited significant inhibition of alpha-glucosidase, with 58.20% inhibition in sucrose substrate and 39.86% inhibition in maltose substrate at 100 μg/mL. Further phytochemical investigation led to the discovery of a new biphenyl compound, macrabiphenyl A, which showed weak activity against the enzyme.