A new monocyclic monoterpene derivative from volva of Phallus dongsun

A new monoterpene derivative namely dongsunol A (1) and sixteen known compounds (2-17) were isolated from the volva of Phallus dongsun. All compounds were isolated from this fungus for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance (NMR), HRESIMS spectral data, and electronic circular dichroism (ECD). The new monoterpene derivative (1) exhibited antibacterial activity with a MIC of 200 mu g/mL. Other compounds have inhibitory effects on Staphylococcus aureus and Pseudomonas aeruginosa, while have displayed moderate NO inhibitory activity and antineoplastic activity on SMMC-7721 and SW480 in vitro.

Automated summary

A new monoterpene derivative called dongsunol A (1) and sixteen known compounds (2-17) were isolated from the volva of Phallus dongsun. The structures and configurations of these compounds were determined using NMR, HRESIMS, and ECD. Compound (1) showed antibacterial activity with a MIC of 200 μg/mL, while the other compounds exhibited inhibitory effects on Staphylococcus aureus and Pseudomonas aeruginosa, as well as moderate NO inhibitory and antineoplastic activities on SMMC-7721 and SW480 in vitro.