Journal
NANOTOXICOLOGY
Volume 17, Issue 4, Pages 310-337Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17435390.2023.2218925
Keywords
Toxicity; diamond nanoparticles; tumor; nanoparticles surface modifications
Categories
Ask authors/readers for more resources
This study evaluated the cytotoxicity of 13 types of diamond nanoparticles with different production methods, sizes, and surface functional groups on tumor cell lines and a non-tumor cell line. The results showed that diamond nanoparticles had no toxicity on non-tumor cells but moderate toxicity on glioblastoma cell lines. The production method did not affect the toxicity, but modifications of the nanoparticles had varying effects on cell response.
Reports on the cytotoxicity of diamond nanoparticles (ND) are ambiguous and depend on the physicochemical properties of the material and the tested cell lines. Thus, the aim of this research was to evaluate the influence of thirteen types of diamond nanoparticles, differing in production method, size, and surface functional groups, on their cytotoxicity against four tumor cell lines (T98G, U-118 MG, MCF-7, and Hep G2) and one non-tumor cell line (HFF-1). In order to understand the dependence of diamond nanoparticles on physicochemical properties, the following parameters were analyzed: viability, cell membrane damage, morphology, and the level of intracellular general ROS and mitochondrial superoxide. The performed analyses revealed that all diamond nanoparticles showed no toxicity to MCF-7, Hep G2, and HFF-1 cells. In contrast, the same nanomaterials were moderately toxic for the glioblastoma T98G and U-118 MG cell lines. In general, the effect of the production method did not influence ND toxicity. Some changes in cell response after treatment with modified nanomaterials were observed, with the presence of carboxyl groups having a more detrimental effect than the presence of other functional groups. Although nanoparticles of different sizes caused similar toxicity, nanomaterials with bigger particles caused a more pronounced effect.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available