Journal
NANOMEDICINE
Volume 18, Issue 9, Pages 769-782Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2023-0082
Keywords
antibacterial; biosensors; DNA; nanoscale silver; silver nanoclusters; silver nanoparticles
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Silver nanoparticles (AgNPs) and silver nanoclusters (AgNCs) are both promising nanomaterials for biomedical applications. AgNPs are versatile drug-delivery carriers, imaging probes, and antibacterial agents, while AgNCs exhibit fluorescence and antibacterial activity due to their molecule-like electron configurations. The template-assisted synthesis of AgNCs using organic molecules as ligands, particularly single-stranded nucleic acids, provides fluorescent and biocompatible materials for other formulations. This mini review discusses the design, characterization, and applications of both AgNPs and DNA-templated AgNCs in antibacterial agents and biosensors.
Silver nanoparticles (AgNPs) are increasingly considered for biomedical applications as drug-delivery carriers, imaging probes and antibacterial agents. Silver nanoclusters (AgNCs) represent another subclass of nanoscale silver. AgNCs are a promising tool for nanomedicine due to their small size, structural homogeneity, antibacterial activity and fluorescence, which arises from their molecule-like electron configurations. The template-assisted synthesis of AgNCs relies on organic molecules that act as polydentate ligands. In particular, single-stranded nucleic acids reproducibly scaffold AgNCs to provide fluorescent, biocompatible materials that are incorporable in other formulations. This mini review outlines the design and characterization of AgNPs and DNA-templated AgNCs, discusses factors that affect their physicochemical and biological properties, and highlights applications of these materials as antibacterial agents and biosensors.
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